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首页> 外文会议>SPIE Conference on Biomedical Applications in Molecular, Structural, and Functional Imaging >A retrospective study of white matter integrity in mildcognitive impairment
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A retrospective study of white matter integrity in mildcognitive impairment

机译：温和认知障碍中白质诚信的回顾性研究

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Prior work has shown that white matter fiber integrity decreases in Alzheimer's disease (AD) and mild cognitive impairment (MCI). This can be achieved by quantifying anisotropic water movement in the brain using diffusion tensor imaging techniques. Since less than half (but still a considerable amount) of the MCI patients convert to AD it is important to identify features that can predict the chance of conversion to AD within a certain time frame. In this study we applied tract-based spatial statistics (TBSS) in order to perform this task, which overcomes limitations that are commonly associated with ROI-based approaches and voxel-based morphometry (VBM). Diffusion weighted images were taken from 15 healthy controls, 15 AD patients and 17 MCI patients. 8 MCI patients remained stable within 3 years of follow-up investigations ("non-converters" or MCI-nc) and 9 converted to AD ("converters" or MCI-c). Significant differences between the MCI-nc and MCI-c groups were found in large parts of the fornix, the corpus callosum and the cingulum. In comparison, the MCI-c group did not differ significantly from the AD group and the MCI-nc group exhibited features similar to the control group in most parts of the structures. These results demonstrate that, although MCI-c and MCI-nc patients were clinically similar at time of inclusion, the MCI-c group already exhibited pathologic features of fiber integrity associated with AD. This finding could lead to more powerful techniques in the early identification of AD and thus support an earlier and more successful treatment.
机译：前工作表明，白质纤维完整性降低了阿尔茨海默病（AD）和轻度认知障碍（MCI）。这可以通过使用扩散张量成像技术量化脑中的各向异性水运动来实现。由于MCI患者的不到一半（但仍然相当大量）转换为广告，因此识别可以预测在特定时间范围内转换到广告的机会的功能非常重要。在这项研究中，我们应用了基于漫流的空间统计（TBS）以执行此任务，该任务克服了与基于ROI的方法和基于voxel的形态学（VBM）共同相关的限制。扩散加权图像取自15例健康对照，15名AD患者和17例MCI患者。 8 MCI患者在3年内保持稳定，后续调查（“非转换器”或MCI-NC）和9转换为广告（“转换器”或MCI-C）。 MCI-NC和MCI-C组之间的显着差异在穹窿，语料库胼um和Cingulum的大部分中发现。相比之下，MCI-C组与广告组和MCI-NC组在结构的大多数部分中表现出类似的特征。这些结果表明，虽然在包含时MCI-C和MCI-NC患者在临床上临床上类似，但MCI-C组已经表现出与AD相关的纤维完整性的病理特征。这一发现可能导致广告早期识别中的更强大的技术，从而支持较早和更成功的治疗。

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