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First phantom and in vivo MPI imageswith an extended field of view

机译：第一个幻像和体内MPI映像扩展视野

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Magnetic Particle Imaging (MPI) is a high-potential new medical imaging modality that has been introduced in 2005. MPI uses the non-linear magnetization behavior of iron-oxide based nano-particles, named tracer, to perform quantitative measurements of their local concentration. Previous publications demonstrated the feasibility of real-time in vivo 3D imaging with clinical concentration of Resovist. Given MPI's fast and sensitive imaging as well as its overall versatility, it has potential to support various medical applications spanning from diagnostics to therapy. As an example, ongoing research investigates the use of MPI in cardiovascular diagnostics for myocardial perfusion measurement. While previous publications reported results from experimental systems with limited bore size (3cm), this contribution presents first phantom and in vivo images acquired on the next hardware generation, an experimental system with an effective bore size of 12cm. The system is designed for pre-clinical studies and can capture image data from an extended field of view compared to the previous, experimental system. The contribution introduces concepts for the encoding of a larger field of view by means of additional magnetic fields, named focus-fields, and outlines the path to stitching of images from multiple focus field settings, called "multi-station reconstruction". To prove the feasibility of imaging of an extended field of view, volumetric images of a moving phantom as well as of a living rat were acquired.
机译：磁性粒子成像（MPI）是2005年推出的高潜能新的医学成像模型。MPI使用基于铁的纳米颗粒的非线性磁化行为，命名的示踪剂，进行局部浓度的定量测量。以前的出版物证明了具有临床集中的Vivo 3D成像的实时性的可行性。考虑到MPI的快速和敏感的成像以及整体多功能性，它有可能支持从诊断到治疗的各种医疗应用。作为一个例子，正在进行的研究研究了MPI在心肌灌注测量中的心血管诊断中的使用。虽然以前的出版物报告了孔径有限（3cm）的实验系统的结果，但是该贡献呈现了在下一个硬件生成上获得的第一幻像和体内图像，实验系统具有12cm的有效孔径的实验系统。该系统专为临床前研究设计，并且与先前的实验系统相比，可以从扩展视野中捕获图像数据。该贡献介绍了通过附加磁场，命名对焦场的额外磁场编码较大视野的概念，并概述了从多个焦点场设置拼接的路径，称为“多站重建”。为了证明扩展视野的成像的可行性，获得了移动幻影以及活大鼠的移动模型的体积图像。

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