• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>SPIE Conference on Biomedical Applications in Molecular, Structural, and Functional Imaging >Normal and Keratoconic Corneal Epithelial Thickness Mapping usingFourier-Domain Optical Coherence Tomography
【24h】

Normal and Keratoconic Corneal Epithelial Thickness Mapping usingFourier-Domain Optical Coherence Tomography

机译：正常和角膜透耳角膜上皮厚度映射使用符号域光学相干断层扫描

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The detection of early-stage keratoconus is one of the most important safety issues in screening candidates for corneal refractive surgeries. We propose to use epithelial thickness maps to assist the diagnosis of keratoconus. The corneal epithelial thickness in normal and keratoconic eyes was mapped with optical coherence tomography (OCT). A Fourier-domain OCT system capable of acquiring 26,000 axial-scans per second was used. It has an axial resolution of gm in cornea. A pachymetry scan pattern (8 radials, 1024 axial-scans each, 6mm diameter, repeat 3 times) centered at the pupil center was used to image the cornea. The 3 repeated radial scans on each meridian were registered and averaged. Then the anterior corneal, posterior corneal and epithelial boundaries were segmented automatically with a computer algorithm by increased signal intensity at corresponding boundaries. The epithelial thickness map was generated by interpolating epithelial thickness profile calculated from each meridian. Normal and keratoconic eyes (24 eyes each) were scanned 3 times. The central epithelial thickness in normal eyes was thicker than those of keratoconic eyes (mean difference 2.1 gm, t-test p=0.05). The epithelium was thinner superiorly than inferiorly in normal eyes (mean difference -1.4±1.1gm, p<0.001) while thicker superiorly than inferiorly in keratoconic eyes (2.014.1 gm, p=0.02).
机译：早期角蛋白的检测是筛选角膜屈光手术的候选者中最重要的安全问题之一。我们建议使用上皮厚度图来帮助诊断角振焦。正常和角振来眼睛的角膜上皮厚度用光学相干断层扫描（OCT）映射。使用能够获得每秒26,000次轴向扫描的傅里叶域OCT系统。它在角膜中具有轴向分辨率。使用瞳孔中心以瞳孔中心为中心的偏心扫描图案（8个径向，1024次轴向扫描，6mm，重复3次）用于图像。每次经络中的3个重复的径向扫描被登记并平均。然后通过增加相应边界的信号强度自动用计算机算法自动分割前角膜，后部角膜和上皮边界。通过内插从每个子午线计算的上皮厚度曲线来产生上皮厚度图。扫描正常和角质胶质眼睛（每次24只眼睛）3次。正常眼中的中央上皮厚度厚度比角振来的眼睛（平均差异2.1克，T-Test P = 0.05）。上皮变薄向上比向下正常眼（平均差-1.4±1.1gm，P <0.001），而更厚的向上向下比在圆锥角膜眼（2.014.1克，p值= 0.02）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号