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首页> 外文会议>NATO Advanced Study Institute on Biodefence: Advanced materials and methods for health protection >Efficacy of Modified Hemosorbents Used for Treatment of Patients with Multi-Organ Insufficiency
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Efficacy of Modified Hemosorbents Used for Treatment of Patients with Multi-Organ Insufficiency

机译：用于治疗多器官功能不全的患者的改性血液血坏的功效

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The treatment of patients with multiple organ failure is one of the most complex problems of modern medicine. The possibility to directly control physi-cochemical characteristics of medical sorbents using different technologies and chemical modification, in particular surface oxidation, is one of the approaches used to improve efficacy of hemosorption. The developed technique of oxidative sorbent modification by treatment with a solution of neutral anolite was used to modify the polymer pyrolyzed active carbon SKN-2 K. The modified hemosorb-ent was used to treat 31 patients with postoperative complications which led to multi-organ deficiency. The positive clinical outcomes included decrease of signs of intoxication syndrome, health improvement, and improvement in biochemical parameters after just one session of hemosorption. The reduction in the level of endogenous intoxication markers was statistically significant after the second session. It was established that the developed hemosorption technique allows the increase in the efficacy of biotransformation and elimination of toxic metabolic products, and stimulates cellular and humoral immune response. The hemosorption performed through a modified sorbent showed a favourable effect on the main parameters of the homeostasis system. The neutral anolite possesses anticoagulant and anti-aggregation properties. This allows for a reduction in heparin dosage during the procedure with the modified sorbent, therefore minimizing homeostasis system complications during the course of detoxification therapy. The total duration of the treatment was reduced by 41% and the hospitalisation period was 4.8 times shorter in comparison with the control group.
机译：多种器官衰竭患者的治疗是现代医学中最复杂的问题之一。使用不同技术直接控制医用吸附剂的物理化学特性和化学改性，特别是表面氧化，是用于改善磨雾功效的方法之一。通过用中性半岩溶液处理的氧化吸附剂改性的开发技术用于改性聚合物热解的活性炭SKN-2 K.修饰的血清素-ENT用于治疗31例术后并发症的患者，导致多器官缺乏。积极的临床结果包括醉酒综合征，健康改善和在一次溶血会议之后的生化参数的迹象减少。在第二次会议后，内源中毒标志物水平的降低在统计学上显着。建立了发育的溶血技术可以增加生物转化和消除毒性代谢产物的疗效，并刺激细胞和体液免疫应答。通过改性的吸附剂进行的溶血对稳态系统的主要参数表现出有利影响。中性半机具有抗凝血和抗聚集性能。这允许在具有改性的吸附剂的过程中减少肝素剂量，因此在排毒治疗过程中最小化稳态系统并发症。治疗的总持续时间减少了41％，与对照组相比，住院时间较短4.8倍。

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