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首页> 外文会议>International Conference on Industry, Information System and Material Engineering >The Effect of Low Extracellular Potassium on Cardiac Arrhythmia Vulnerability: A Computer Simulation Study
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The Effect of Low Extracellular Potassium on Cardiac Arrhythmia Vulnerability: A Computer Simulation Study

机译：低细胞外钾对心律失常脆弱性的影响：计算机仿真研究

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摘要

Unidirectional conduction block of cardiac excitation wave is one of the necessary conditions leading to initiation of reentrant arrhythmia. Temporal vulnerable window (VW_(time)) is an important measure for arrhythmia vulnerability. In this study, we examine theoretically how low extracellular K concentration ([K]_o) control the VW_(time) by a single premature extrasystole. A numerical modified LR91 one dimensional heterogeneous ventricular model is used to quantitatively investigate the relation of low [K]_o with conduction velocity (CV), VW_(time), and electrical dynamic factor CV restitution. Morever, we characterize the distribution of Na channel conductance (g_(Na)) and gating factors of premature beat applied at different time of the VW_(time) with different [K]_o. The results show that lowering [K]_o enlarge the VW_(time) magnitude gradually. The CV of S1 beat slows down with the [K]_o in a reverse-[K]_o dependent manner. Low [K]_o promote the recovery of maximum Na conductance (G_(Na)) from inactivation. However, decreasing [K]_o can increase heterogeneity of g_(Na) along the cable, and modulate CV restitution curve, which induce larger transmutable dispersion of refractoriness for the premature beat and enlarge the VW_(time).
机译：心脏激发波的单向传导块是导致再入心律失常引起的必要条件之一。时间弱势窗口（VW_（TIME））是心律失常漏洞的重要措施。在这项研究中，理论上，从理论上检查单个过早升级渗透渗透压的细胞外k浓度（[k] _o）控制VW_（时间）。数值改性的LR91一维异质室模型用于定量研究低[K] _O与传导速度（CV），VW_（TIME）和电动态因子CV恢复的关系。更多，我们表征了Na通道电导的分布（G_（NA））和施加在VW_（TIME）的不同时间的过早搏动的门控因子与不同的[k] _o。结果表明，降低[k] _o逐渐扩大VW_（时间）幅度。 S1搏动的CV在反向[k] _o依赖的方式中，用[k] _o减慢。低[k] _O促进灭活的最大NA电导的回收率（G_（NA））。然而，减小[k] _o可以沿电缆增加G_（NA）的异质性，并调制CV恢复曲线，该曲线诱导耐火性的较大可转换色散，以便过早地搏动并扩大VW_（时间）。

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