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首页> 外文会议>Asia-Pacific Conference of tumor biology and medicine >Increased expression of CD146 and microvessel density (MVD) in invasive micropapillary carcinoma of the breast: Comparative study with invasive ductal carcinoma-not otherwise specified
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Increased expression of CD146 and microvessel density (MVD) in invasive micropapillary carcinoma of the breast: Comparative study with invasive ductal carcinoma-not otherwise specified

机译：CD146和微血管密度（MVD）在乳腺癌侵袭性微癌癌中的表达增加：对比研究与侵袭性导管癌 - 未另行指定

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Invasive micropapillary carcinoma (IMPC) is a rare variant of ductal carcinoma of the breast and is characterized by high metastatic potential and an aggressive clinical course. Studies of CD146 expression and function in breast cancer remain scarce. The aim of this study was to evaluate the role of CD146 and microvessel density (MVD) in breast IMPC.CD146 mRNA expression and immunohistochemistry for CD146 and MVD measured by CD31were assessed in eighty-two cases of IMPC and 137 cases of invasive ductal carcinoma, not otherwise specified (IDC-NOS). The mRNA level of CD146 in cancer specimens was higher in IMPC than IDC-NOS.CD146 expression in tumor cells was up-regulated in IMPC compared with that in IDC-NOS and was positively correlated with histological grade, ER, PR status, and P53 expression in IMPC and IDC-NOS. CD146 expression in vascular endothelial cells was significantly higher than that in IDC and was positively correlated with tumor progression in IMPC and IDC-NOS. MVD in IMPC was significantly higher than that in IDC. CD 146 expression in tumor cells was positively correlated with that in vascular endothelial cells of IMPC and IDC-NOS. The association of CD 146 expression with MVD and its correlation with progression in breast carcinoma indicated that CD146 is a potentially useful prognostic marker for breast cancer. CD146could be a new drug target in the treatment of breast cancer.
机译：侵袭性微癌癌（IMPC）是乳房导管癌的罕见变体，其特征在于高转移性潜力和侵略性的临床过程。 CD146表达和乳腺癌功能的研究仍然稀缺。本研究的目的是评估CD146和微血管密度（MVD）在乳房IMPC.CD146 mRNA表达和免疫组织中的作用，用于通过CD31were测量的CD31和MVD在IMPC中的82例和137例侵入性导管癌中测量，未指定（IDC-NO）。癌症标本中CD146的mRNA水平在IMC-NOS.CD146与IMC中的IDC-NOS.CD146表达较高，与IDC-NOS中的肿瘤上调，并与组织学级，ER，PR状态和P53呈正相关IMPC和IDC-NO中的表达。血管内皮细胞中的CD146表达明显高于IDC中的表达，并与IMPC和IDC-NO的肿瘤进展呈正相关。 IMVC中的MVD显着高于IDC。肿瘤细胞中的CD 146表达与IMPC和IDC-NOS的血管内皮细胞中的表达呈正相关。 CD 146表达与MVD的关系及其与乳腺癌进展的相关性表明CD146是乳腺癌的潜在有用的预后标志物。 CD146可以是治疗乳腺癌的新药靶标。

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