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首页> 外文会议>St. Gallen EORTC Gastrointestinal Cancer Conference >Why is there a change in patterns of GE cancer?
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Why is there a change in patterns of GE cancer?

机译：为什么GE癌症的模式发生变化？

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Recent decades have seen a worrying trend in incidence rates of distal oesophageal and proximal gastric cancers. Fuelled by radical changes in lifestyle, diet, physical activity and environmental exposures, as well as an ageing population and host genetic predisposition, the incidence of oesophageal adenocarcinoma (OAC) is on the rise in Western populations. While overall incidence of gastric cancers is declining, the ageing of society means that an increase in absolute numbers is expected over coming years. Both cancers tend to present at an advanced stage, hence prognosis remains poor despite increasingly effective screening and treatment strategies. The development of gastric and oesophageal malignancies is influenced by myriad factors, not least geographical, racial and socioeconomic differences in addition to lifestyle choices. The multidimensional nature of these risk factors requires a holistic understanding of their net influence in the development of malignancy. This review explores the evidence base for established and putative risk factors in the development of gastric and oesophageal cancers. It is hoped that with a clear understanding of important risk factors, a multidisciplinary approach including effective primary prevention, regular screening of high-risk groups and continued research into the molecular biology of gastrointestinal carcino-genesis may facilitate a reduction in incidence rates, as well as early detection and optimal management of upper gastrointestinal malignancies.
机译：近几十年来，在食管远端和近端胃癌的发生率令人担忧的趋势。由生活方式的彻底改变，饮食，身体活动和环境的风险，以及人口老龄化和主机的遗传倾向，食管腺癌（OAC）的发病率的推动是在西方人群呈上升趋势。虽然胃癌的总发病率正在下降，社会手段，在绝对数量的增加，预计在未来几年的老化。这两种癌症往往出现在一个先进的阶段，因此预后仍尽管越来越有效的筛查和治疗策略不佳。胃食管和恶性肿瘤的发展受到众多因素的影响，除了生活方式的选择并非最不重要的地域，种族和社会经济差异的影响。这些危险因素的多面性，需要他们在恶性肿瘤的发展净影响一个全面的了解。本次审查探讨了在胃和食管癌症的发展建立和公认的危险因素的证据基础。人们希望，随着重要的危险因素，一个清醒的认识，多学科的方法，包括有效的一级预防，高危人群的定期筛查，并继续研究胃肠carcino-起源的分子生物学会促进发病率的减少，以及作为早期检测和上消化道恶性肿瘤的最佳管理。

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