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首页> 外文会议>International Congress Arsenic In The Environment >Synergistic toxic effects among arsenic, chromium and copper associated with chrome copper arsenate-treated wood
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Synergistic toxic effects among arsenic, chromium and copper associated with chrome copper arsenate-treated wood

机译：砷，铬和铜之间的协同毒性效应与铬铜砷化铜的木材

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The neurotoxicity of Arsenic (As) associated with Chrome Copper Arsenate (CCA)-treated wood when accompanied by chromium and copper was studied. Cells of the human neuroblastoma line SK-N-SH were cultured with CCA-treated wood leachates or with solutions containing pentavalent arsenic [As(V)], divalent copper [Cu(II)], trivalent chromium [Cr(III)] alone or in different combinations of the three elements. The toxicity was evaluated using variations in cell replication compared to controls after 96 h exposure. Exposure of SK-N-SH to CCA-treated wood leachates resulted in inhibition of cell proliferation and cell death depending on the exposure concentration, with the EC50 for cell death for As(V) in wood leachates (10.7 μM)) at lower values than for As alone (21.1 μM). As(V) toxicity was enhanced with the presence of Cu(II), while decreased with Cr(III). Dissolved Organic Matter (DOM) reduced the adsorption of As(V), but enhanced the uptake of Cr(III) into the test cells.
机译：研究了与铬铜砷镓（CCA） - 加铬的砷化铜（CCA）铜的神经毒性进行了研究。用CCA处理的木渗滤液或用含有五价砷的溶液培养人神经母细胞瘤线SK-N-SH的细胞，二价铜[Cu（II）]，单独的三价铬[Cr（III）]或以三个元素的不同组合。与96小时暴露后的对照相比，使用细胞复制的变化评估毒性。 SK-N-SH对CCA处理的木渗滤液导致抑制细胞增殖和细胞死亡，这取决于曝光浓度，EC50在木渗滤液（10.7μm）中以较低值而不是单独（21.1μm）。随着（v）毒性随着Cu（II）的存在而增强，同时用Cr（III）降低。溶解有机物（DOM）降低了As（V）的吸附，但增强了Cr（III）的吸收到测试细胞中。

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