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首页> 外文会议>World Congress on Immunopathology Respiratory Allergy >The effect of C3 and C4 complement components on allergic rhinitis patients referred to Amir al-Momenin hospital of Zahedan city
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The effect of C3 and C4 complement components on allergic rhinitis patients referred to Amir al-Momenin hospital of Zahedan city

机译：C3和C4补体组分对Zahedan City al-Momenin医院Amir Al-Momenin医院的过敏性鼻炎患者的影响

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Background and Objectives: Initially the complement system was introduced for destroying microbe or erythrocytes that were sensitized with antibody. It is now clear that this system with composition of several serum proteins and cellular receptors, relates to the immunopathologic reactions to several diseases such as allergic rhinitis. The aim of this study was to investigate the role of C3 and C4 as inflammatory and anaphylatoxic reaction markers in patients suffering from allergic rhinitis in Zahedan city to determine serum levels of these components in relation with their serum specific IgE antibodies. Material and methods: This analytic and descriptive study was carried out in 176 allergic rhinitis patients. Periphery blood sample was taken after completion demographic questioner forms from each patients sex and age matched with healthy control. Serum was taken and analysed for measurement of C3 and C4 levels by nephlometry methods. The exact amount of total IgE component was measured by ELISA method. The results were analyzed by SPSS, 15.0 programme. Results: From 176 patients, 21% had increased amount of C3 and 6% had decreased amount of this component whereas only 28 had increased amount of C4 and 16% had decreased amount of this component. In healthy control the C3 level was within the normal range and C4 level had increased in a %2 of them). The exact amount of serum IgE concentration had increased in 76% in contrast with normal individuals, 5% of them had increased the exact amount of serum IgE. Conclusions: The results of this study indicated that the complement system activation and concentration of C3 and C4 in allergic rhinitis are involved in the immunopathology of allergic rhinitis. Further study is required to investigate more the complement cleavage products of C3 and C4 and other components and the activation of their corresponding receptors in cells regulate the development of specific immunity such as Th2 responses of allergic rhinitis patients.
机译：背景和目的：最初引入了破坏用抗体敏化的微生物或红细胞的补体系统。现在清楚的是，该系统具有几种血清蛋白和细胞受体的组成，涉及对几种疾病如过敏性鼻炎的免疫病理反应。本研究的目的是探讨C3和C4作为患有Zahedan City中过敏性鼻炎的患者的炎症和过敏性反应标志物的作用，以确定与其血清特异性IgE抗体相关的这些组分的血清水平。材料和方法：该分析和描述性研究是在176例过敏性鼻炎患者中进行的。在完成与健康控制匹配的每位患者性和年龄的患者和年龄的患者中，术后外围血液样本。通过肾小值方法进行血清并分析测量C3和C4水平。通过ELISA方法测量总IgE成分的确切量。结果由SPSS，15.0节目分析。结果：从176例患者，21％的C3和6％的含量增加了该组分的量减少，而仅28例增加的C 4和16％的该组分减少了10％。在健康控制中，C3水平在正常范围内，C4水平在其中2％中增加。与正常的个体相比，血清IgE浓度的确切量增加了76％，其中5％增加了血清IgE的确切量。结论：本研究的结果表明，过敏性鼻炎中的补体系统激活和C3和C4的浓度参与了过敏性鼻炎的免疫病理学。进一步的研究需要进行更多的C3和C4和其他组分的补体裂解产物，并且其相应的细胞中的相应受体的激活调节特定免疫的发展，例如过敏性鼻炎患者的响应。

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