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首页> 外文会议>International Conference on Advances Science and Contemporary Engineering >Simulation of Passive Fluid Driven Micromixer for Fast Reaction Assays in Nano lab-on-chip Domain
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Simulation of Passive Fluid Driven Micromixer for Fast Reaction Assays in Nano lab-on-chip Domain

机译：纳米实验室结构域快速反应测定的无源流体驱动微混合器的仿真

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. The article contains report on simulation of micromixer that takes the advantage of capillary phenomena to mix fluids. Microlaboratories for biochemical applications often require rapid mixing of different fluid streams. At the microscale, flow is usually highly ordered laminar flow, and the lack of turbulence makes diffusion the primary mechanism for mixing. While diffusional mixing of small molecules can occur in a matter of seconds over distances of tens of micrometers, mixing of larger molecules such as peptides, proteins, and high molecular-weight nucleic acids can require equilibration times from minutes to hours over comparable distances. Such delays are impractically long for many chemical analyses. These problems have led to an intense search for more efficient mixers for microfluidic systems most microscale mixing devices are either passive mixers that use geometrical stirring or active mixers that use moving parts or external forces, such as pressure or electric field. In a passive mixer, one way of increasing the mixing is by "shredding" two or several fluids into very thin alternating layers, which decreases the average diffusion length for the molecules between the different fluids. Another way of improving mixing efficiency is to use active mixers with moving parts that stir the fluids. At the microscale level moving parts in an active mixer are very fragile. One alternative is to use capillary effects to achieve a mixing effect that is perpendicular to the main direction of the flow. Thus here, the design is based on differential pressure drop flow using capillary effect concept which has facilitated a number of interesting flow phenomena in micro-domains. For an average pressure drop of about 100/m in the setup, flow rates of bout 0.7 to 1 μ1/s were obtained. The component consists of a microchannels, three designs were tested (50, 70, 90 microns in width) to give a continuous open circuit flow. The system was designed for continuous flow across sensing element where there is a requirement for low residence time due to fast reaction/diffusion rates.
机译：。本文包含有关仿真器的仿真报告，其利用毛细管现象来混合流体。生化应用的微型制剂通常需要快速混合不同的流体流。在微尺度下，流量通常是高度有序的层流，并且缺乏湍流使得扩散成为混合的主要机制。虽然小分子的扩散混合可以在几十微米的距离的几秒钟内发生，但混合诸如肽，蛋白质和高分子量核酸的较大分子可以要求在比较距离上从分钟到小时的平衡时间。对于许多化学分析，这种延迟是不切实际的。这些问题导致了对微流体系统的更高效的混合器的激烈搜索大多数微尺​​度混合装置是无源混合器，这些无源混合器使用使用移动部件或外力的几何搅拌或有源混合器，例如压力或电场。在无源混合器中，增加混合的一种方式是将“粉碎”两个或多个流体中的非常薄的交替层，这降低了不同流体之间分子的平均扩散长度。改善混合效率的另一种方式是使用具有搅拌流体的移动部件的活性混合器。在主电影的微观级别移动部件处于有源混频器中非常脆弱。一种替代方案是使用毛细管效果来实现垂直于流动的主方向的混合效果。因此，在这里，设计基于使用毛细管效应概念的差压下降流，这促进了微域中的许多有趣的流动现象。对于设置在设置中的平均压力下降约100 / m，获得了0.7至1μl/ s的流量。该组件由微通道组成，测试三种设计（宽度为50,70,90微米），以提供连续开路流。该系统被设计用于对传感元件的连续流动，其中由于快速反应/扩散速率，存在低停留时间的要求。

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