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首页> 外文会议>International Conference on Biomedical Electronics and Devices >A Targeting Self-breakable Agent for Increased Efficacy of Chemotherapeutic Drugs against Caco2 Cells
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A Targeting Self-breakable Agent for Increased Efficacy of Chemotherapeutic Drugs against Caco2 Cells

机译：一种靶向可自折叠剂，用于增加化学治疗药物对CaCO2细胞的疗效

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Many types of nano-sized anti-cancer agents that could increase efficacy of chemotherapeutic drugs have been created and developed in colon cancer treatment over years. Moreover, with the intention of achieving the ideal chemotherapeutic efficacy, nano-sized anti-cancer agents were further designed to have specific functions, efficiently killing colon cancer cells. Our research team focused on two important functions in designing nano-sized agents, controlled drug release and targeting functions. Thus, targeting functional micelles which entrapped chemotherapeutic drug, 7-ethyl-10-hydroxy-camptothecin (SN38) were designed in nano-size and possessed disulfide bonds in this study. In particular, Self-Breakable SN38-loaded micelles (SN/38 micelles), Non-Breakable micelles SN38-loaded (NB/38 micelles) and Folate-targeting Self-Breakable SN38-loaded micelles (FSB/38 micelles) were prepared and tested to the designed agents. The results showed that the folate-decorated functional micelles with disulfide bonds could be an effective chemotherapeutic agent for colon cancer treatment.
机译：许多类型的纳米大小的抗癌药物，可以提高化疗药物的疗效已创建并在结肠癌治疗过几年发展起来的。此外，与实现理想的化学治疗功效的意图，纳米尺寸的抗癌剂进一步设计为具有特定的功能，有效地杀死结肠癌细胞。我们的研究团队主要集中在两个重要的功能在设计纳米级药物，控制药物释放和定位功能。因此，针对该截留化疗药物官能胶束，7-乙基-10-羟基喜树碱（SN38）被设计在本研究的纳米尺寸且具二硫键。特别是，自身易破裂SN38加载的胶束（SN / 38胶束），不易碎胶束SN38加载（NB / 38胶束）和叶酸靶向自身易破裂SN38加载的胶束（FSB / 38胶束）中制备和测试所设计的代理商。结果表明，与二硫键的叶酸装饰功能胶束可以是用于结肠癌治疗的有效化疗剂。

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