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首页> 外文会议>International Conference on Biotechnology, Chemical and Materials Engineering >Isolated Strains of Nontuberculous Mycobacterium Interfere with Immune Responses Associated with Mycobacterium bovis BCG Vaccination
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Isolated Strains of Nontuberculous Mycobacterium Interfere with Immune Responses Associated with Mycobacterium bovis BCG Vaccination

机译：孤立的非萎缩分枝杆菌的菌株干扰与肉杆菌BCG疫苗接种的免疫应答

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摘要

Prior exposure of a vaccine to certain species of environmental mycobacteria can prime the immune system against common mycobacterial antigens, which can in turn reduce the subsequent efficacy of live attenuated mycobacterial vaccines (such as Mycobacterium bovis BCG), in both human and livestock vaccination programs. In this study, five strains of nontubeculous mycobacterium, all isolated from lymphonodi mandibulares and lymphonodi mesenterici samples of swine and cattle, were investigated to determine their growth characteristics and effects on the immune system in murine models. Markedly, different effects on the immune system were observed. The different results may be linked to the inherent growth characteristics of the five strains, The implications of these findings for BCG vaccination protocols are discussed.
机译：在某些环境中，对某些环境分枝杆菌的预见疫苗可以使免疫系统抵抗普通的分枝杆菌抗原，其又可以减少人类和牲畜疫苗接种程序中的活病毒病变疫苗（例如BOVIS BCG）的后续疗效。在这项研究中，研究了五种非解点的猪和牛的淋巴管颌骨和淋巴管米森菌样品的五种菌株，以确定其对鼠模型的免疫系统的生长特征和影响。显着，观察到对免疫系统的不同影响。不同的结果可能与五种菌株的固有生长特征相关，讨论了这些发现对BCG疫苗接种方案的影响。

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