Complexity of Viruses and the Type I Interferon System: Towards Understanding the Role of Plasmacytoid Dendritic Cells During Porcine Infections

机译：病毒的复杂性和I型干扰素系统：为了了解猪感染期间血浆骨质树突细胞的作用

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Interferon type I (IFN-I), which is composed of IFN-a subtypes and IFN-p, is not only a potent antiviral factor against many but not all viruses but also represents an important alarm system of the immune system. Of particular relevance for virus infections are the ability of IFN-I to promote crucial processes leading to effector and memory adaptive immune responses. In particular IFN-I promotes the activation and maturation of dendritic cells (DC), the development and activation of cytotoxic T lymphocytes, the activation of natural killer cells and the development of B lymphocytes differentiation towards antibody secreting plasma cells and memory B lymphocytes.

机译：由IFN-A亚型和IFN-P组成的干扰素类型I（IFN-I）不仅是对许多但不是所有病毒的有效抗病毒因素，而且代表了免疫系统的重要报警系统。特别关联的病毒感染是IFN-I促进关键方法导致效应和记忆自适应免疫反应的能力。特别地，IFN-I促进树突细胞（DC）的活化和成熟，细胞毒性T淋巴细胞的发育和激活，自然杀伤细胞的激活以及B淋巴细胞的发育朝向抗体分泌血浆细胞和记忆B淋巴细胞的分化。

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《Annual Meeting of The American College of Veterinary Pathologists/American Society for Veterinary Clinical Pathology》|2012年||共5页
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Artur Summerfield;
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1. Partial Activation of Natural Killer and γδ T Cells by Classical Swine Fever Viruses Is Associated with Type I Interferon Elicited from Plasmacytoid Dendritic Cells [J] . Giulia Franzoni, Jane C. Edwards, Nitin V. Kurkure, Clinical and vaccine immunology: CVI . 2014,第10期

机译：猪瘟病毒对部分自然杀伤因子和γδT细胞的激活作用与浆细胞样树突状细胞产生的I型干扰素有关。
2. Type I interferon production by plasmacytoid dendritic cells and monocytes is triggered by viruses, but the level of production is controlled by distinct cytokines. [J] . Gary Gouy H, Lebon P, Dalloul AH Journal of interferon and cytokine research: The official journal of the International Society for Interferon and Cytokine Research . 2002,第6期

机译：浆细胞样树突状细胞和单核细胞产生的I型干扰素是由病毒触发的，但其产生的水平由独特的细胞因子控制。
3. Cutting Edge: Peyer’s Patch Plasmacytoid Dendritic Cells (pDCs) Produce Low Levels of Type I Interferons: Possible Role for IL-10, TGFβ, and Prostaglandin E2 in Conditioning a Unique Mucosal pDC Phenotype [J] . Nikhat Contractor, Jennifer Louten, Leesun Kim, The journal of immunology . 2007,第5期

机译：前沿：Peyer的浆细胞浆样树突状细胞（pDC）产生低水平的I型干扰素：IL-10，TGFβ和前列腺素E2在调节独特的粘膜pDC表型中可能发挥作用
4. Complexity of Viruses and the Type I Interferon System: Towards Understanding the Role of Plasmacytoid Dendritic Cells During Porcine Infections [C] . Artur Summerfield Annual Meeting of The American College of Veterinary Pathologists/American Society for Veterinary Clinical Pathology . 2012

机译：病毒的复杂性和I型干扰素系统：为了了解猪感染期间血浆骨质树突细胞的作用
5. Evaluating the role of dendritic cells in host immune response during human T cell leukemia virus type 1 (HTLV-1) infection using a transgenic mouse model system [D] . Rahman, Saifur 2010

机译：使用转基因小鼠模型系统评估树突状细胞在人T细胞白血病病毒1型（HTLV-1）感染期间宿主免疫反应中的作用
6. North American Porcine Reproductive and Respiratory Syndrome Viruses Inhibit Type I Interferon Production by Plasmacytoid Dendritic Cells [O] . Gabriela Calzada-Nova, William M. Schnitzlein, Robert J. Husmann, 2011

机译：北美猪繁殖与呼吸综合症病毒抑制浆细胞样树突状细胞产生I型干扰素
7. North American Porcine Reproductive and Respiratory Syndrome Viruses Inhibit Type I Interferon Production by Plasmacytoid Dendritic Cells ▿ [O] . Calzada-Nova, Gabriela, Schnitzlein, William M., Husmann, Robert J., 2010

机译：北美猪繁殖与呼吸综合症病毒抑制浆细胞样树突状细胞产生I型干扰素

Complexity of Viruses and the Type I Interferon System: Towards Understanding the Role of Plasmacytoid Dendritic Cells During Porcine Infections

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