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首页> 外文会议>International Conference on Applied Materials and Electronics Engineering >Preparation and Characterization of Folate-Decorated Chitosan Microspheres as a Sustained-Release Drugs Carrier
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Preparation and Characterization of Folate-Decorated Chitosan Microspheres as a Sustained-Release Drugs Carrier

机译：叶酸壳聚糖微球的制备与表征作为持续释放的药物载体

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Folic acid-chitosan (FA-CTS) and 10-hydroxycamptothecin (HCPT)-loaded folate-conjugated chitosan (FA-CTS/HCPT) microspheres were prepared by the ionic crosslinking method.The morphological characteristics of microspheres were examined using a scanning electron microscope (SEM). The average particle size and size distribution were determined by dynamic light scattering. The drug encapsulation efficiency (EE) , loading capacity (LC)and release characteristics in vitro were determined using ultraviolet spectrophotometer.Thc results shown that the microspheres are uniform spherical and regular with a size between 19.79 and81.40um. Optimized preparation parameters lead to the successful preparation of hydroxycamptothecin-loaded folate-conjugated chitosan microspheres characterized with encapsulation efficiency and loading capacity up to (86.8±0.1)% and 20.6±0.3 % respectively. More then 90% of 10-hydroxycamptothecin was released from microspheres in 4 h at artificial gastric juice, 8h at artificial small intestinal fluid with a good delayed release effect.
机译：通过离子交联法制备叶酸 - 壳聚糖（FA-CTS）和10-羟基清除素（HCPT）加载的叶酸偶联的壳聚糖（FA-CTS / HCPT）微球。使用扫描电子显微镜检查微球的形态学特性（SEM）。通过动态光散射确定平均粒度和尺寸分布。使用紫外分光光度计测定体外药物包封效率（EE），加载能力（LC）和释放特性。结果表明，微球是均匀的球形和规则，尺寸在19.79和81.40um之间。优化的制备参数导致成功制备羟基清除素加载的叶酸型壳聚糖微球，其特征在于包封效率和加载能力，分别增加（86.8±0.1）％和20.6±0.3％。较多，在人工胃液中，90％的10-羟基清除素蛋白在人工胃液中从微球释放，在人工小肠流体下8小时，具有良好的延迟释放效果。

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