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首页> 外文会议>World Congress of Veterinary Dermatology >Comparison of hair follicle histology between horses with pituitary pars intermedia dysfunction and excessive hair growth and normal aged horses
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Comparison of hair follicle histology between horses with pituitary pars intermedia dysfunction and excessive hair growth and normal aged horses

机译：垂体腺癌毛囊组织学的比较脑垂体患者功能障碍和过度毛发生血清马匹

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Background - Pituitary pars intermedia dysfunction (PPID) in older equids is commonly recognized by a long hair coat that fails to shed.Objective - The aim of this study was to compare hair follicle stages in PPID-affected horses with excessively long hair coats with the stages of normal aged horses (controls) and to compare hair follicle stages in PPID-affected horses after 6 months oftreatment with pergolide mesylate with those of control horses.Animals - Eight PPID-affected horses and four normal, age-matched, control horses.Methods - Skin biopsies were collected from the neck and rump of PPID-affected and control horses. A diagnosis of PPID was established based on hair coat changes and supportive overnight dexamethasone suppression test results. Skin biopsies were repeatedafter 6 months of treatment with pergolide. The number of hair follicles in anagen (A) or telogen (T) was counted for each skin biopsy using transverse sections.Results - Pretreatment biopsies had a greater percentage of A follicles (neck 96%, rump 95%) and a lower percentage of T follicles (neck 4%, rump 5%) in PPID-affected horses than in control horses (A, neck 15%, rump 25%; and T, neck 85%, rump 75%). Aftertreatment with pergolide, all PPID-affected horses had improved shedding, and the percentages of A follicles (neck 69%, rump 70%) and T follicles (neck 31 %, rump 30%) were not different from untreated control horses (A, neck 68%, rump 82%; and T, neck32%, rump 18%).Conclusions - These findings document that excessive hair growth (hypertrichosis) in PPID-affected horses is due to persistence of hair follicles in A. Furthermore, treatment with pergolide improved shedding and reduced the percentage of A follicles in PPID-affected horses.
机译：背景 - 脑垂体置于较旧的交错（PPID）较旧的交叉（PPID）通常由未能脱落的长发涂层识别。对该研究的目的是将受影响的马匹的毛囊阶段与过多的头发涂层进行比较八PPID，受影响的马和四个正常，年龄匹配，控制马 - 正常老年人马（控制）和毛囊阶段PPID影响马6个月oftreatment后甲磺酸培高利特与对照horses.Animals的比较阶段。方法 - 从受PPID受影响和对照马的颈部和臀部收集皮肤活组织检查。基于毛发涂层改变和支持过夜地塞米松抑制试验结果建立了PPID的诊断。皮肤活组织检查重复6个月的突出龙隆治疗。使用横截切片对每个皮肤活组织检查计数Anagen（A）或遥距（T）的毛囊的数量。结果 - 预处理活组织检查的卵泡百分比（颈部96％，臀部95％）和较低的百分比Ť卵泡（颈部4％，臀5％）在PPID-受影响的马比对照马（A，颈部15％，臀25％;和T，颈部85％，臀75％）。随后与痛苦，所有PPPID受影响的马匹都改善了脱落，卵泡（颈部69％，臀部70％）和T卵泡（颈31％，臀部30％）的百分比与未经处理的对照马没有不同（A，颈部68％，臀部82％;和t，颈部32％，臀部18％）。结论 - 这些调查结果文献，受到PPID患者的过度毛发生生长（高血压）是由于A中的毛囊持续存在。此外，治疗Pergolide改善了脱落，并降低了受PPID受影响的马匹中的卵泡百分比。

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