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首页> 外文会议>World Congress of Veterinary Dermatology >Prevalence of and risk factors for isolation of meticillin-resistant Staphylococcus spp from dogs with pyoderma in northern California, USA
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Prevalence of and risk factors for isolation of meticillin-resistant Staphylococcus spp from dogs with pyoderma in northern California, USA

机译：美国北加州狗犬致毛虫耐毛霉菌葡萄球菌SPP的患病率和危险因素

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Background - Canine pyodermas associated with meticillin-resistant Staphylococcus spp. (MRS) have increased in prevalence over the past decade.Hypothesis/Objectives - To compare the prevalence of MRS isolation from dogs with superficial pyoderma at a primary care clinic (PCC) and those at a tertiary care facility (VMTH) in California, USA, and identify associated risk factors.Animals - Client-owned dogs from the VMTH (80 dogs) and the PCC (30 dogs).Methods - Aerobic bacterial culture and antibiotic susceptibility were performed on swab specimens collected from dogs, and meticillin resistance was determined using microdilution methods according to Clinical and Laboratory Standards Institute guidelines. A mecA gene PCR assay was used to confirm meticillin resistance when possible.Results - Of 89 staphylococcal isolates from the VMTH, 34 (38.2%) were meticillin resistant. In 31 dogs, pyoderma persisted, and one or more follow-up isolates were obtained. The species isolated and drug susceptibility changed unpredictably during treatment. Of 33 PCC isolates, nine (27.3%) were meticillin resistant. Multiple drug resistance was identified in 41 of 53 (77.3%) MRS isolates from the VMTH and five of nine from the PCC. The sensitivity and specificity of PCR for the detection of meticillinresistance was 34 of 39 (87%) and 86 of 87 (99%), respectively. Risk factors for meticillin resistance for both sites were antibiotic treatment within the last year (P = 0.001), and for VMTH, hospitalization of dogs within the last year (P = 0.001).Conclusions and clinical importance - The prevalence of meticillin resistance was not different between VMTH and PCC isolates (P = 0.29). Previous antimicrobial therapy was an important risk factor for the isolation of MRS at both sites.
机译：背景 - 与耐甲氧西林葡萄球菌属关联犬pyodermas。 （MRS）已在流行，在过去decade.Hypothesis /目标提高 - 要在基层医疗诊所（PCC）和那些在美国加利福尼亚州的一个三级医疗机构（VMTH）比较MRS隔离从犬脓皮病肤浅的流行，并确定相关的风险factors.Animals - 客户端所属的狗从VMTH（80种狗）和PCC（30只狗）。方法 - 被拭子上进行好氧细菌培养及药敏标本收集狗，并测定耐甲氧西林使用根据临床和实验室标准化研究所准则稀释法。甲mecA基因的PCR测定法来确认甲氧西林抗性时possible.Results - 从VMTH，34（38.2％）89个金黄色葡萄球菌分离株耐甲氧西林。在31种狗，脓皮病依然存在，并获得一个或多个后续分离。物种隔离和治疗期间药物的敏感性不可预知的变化。 33个PCC分离株，9（27.3％）是耐甲氧西林。多重耐药性中的从VMTH 53（77.3％）的MRS菌株和九个从PCC 5 41被确定。 PCR的用于检测meticillinresistance的灵敏度和特异性分别为39（87％）和87（99％）86 34，。风险因素为这两个网站甲氧西林耐药率均去年（P = 0.001）内的抗生素治疗，并为VMTH，在过去一年内狗的住院（P = 0.001）。结论和临床意义 - 甲氧西林耐药的患病率是不VMTH和PCC株（P = 0.29）之间的不同。上一页抗菌治疗是对MRS的两个站点隔离的重要危险因素。

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