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Plasma Adiponectin Lowering after left Ventricular Assist Device Implantation is Associated with 1-Month Survival in Patients with Advanced Heart Failure

机译：降低左心室辅助装置植入后降低血浆脂联素与晚期心力衰竭患者的1个月存活相关

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In advanced heart failure (HF) patients, high circulating levels of adiponectin, an adipokine known to mediate metabolic and anti-inflammatory effects in the heart, are associated to a negative outcome. In order to evaluate adiponectin as a possible prognostic biomarker, we investigated the effect of implantation of left ventricular assist devices (LVAD) on circulating adiponectin levels. Mechanical unloading of the failing myocardium by LVAD implant induced an early decrease of adiponectin plasma levels, mainly in survivor patients, suggesting that early monitoring of adiponectin may be a reliable tool for outcome prediction in LVAD recipients.

机译：在晚期心力衰竭（HF）患者中，脂肪素的高循环水平，一种众所周知的己二酸蛋白在心脏中介导代谢和抗炎作用，与负面结果相关。为了评估脂肪蛋白作为可能的预后生物标志物，我们研究了左心室辅助装置（LVAD）对循环脂联素水平的影响。通过LVAD植入物失败的心肌机械卸载诱导脂联素血浆水平的早期降低，主要是在幸存者患者中，表明早期监测脂联素可能是LVAD受体中的结果预测的可靠工具。

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《International Congress on Coronary Artery Disease.》|2013年||共3页
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DAmico A.; Caruso S.; Cabiati M.; Prescimone T.; Verde A.; Del Ry S.; Trivella M.G.; Giannessi D.; Caselli C.;
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中图分类冠状动脉（粥样）硬化性心脏病（冠心病）;
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1. Pre-operative redox state affects 1-month survival in patients with advanced heart failure undergoing left ventricular assist device implantation. [J] . Caruso R, Garatti A, Sedda V, The Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation . 2007,第11期

机译：接受左心室辅助装置植入的晚期心力衰竭患者的术前氧化还原状态影响其1个月生存。
2. Implantable cardioverter-defibrillators and survival in advanced heart failure patients with continuous-flow left ventricular assist devices: a systematic review and meta-analysis [J] . Elkaryoni Ahmed, Al Badarin Firas, Khan Muhammad Shahzeb, Europace: European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology . 2019,第9期

机译：植入的心脏病 - 除颤器和生存期晚期心力衰竭患者连续流动左心室辅助装置：系统评价和荟萃分析
3. Comparison of functional capacity in patients with end-stage heart failure following implantation of a left ventricular assist device versus heart transplantation: results of the experience with left ventricular assist device with exercise trial. [J] . Jaski BE, Lingle RJ, Kim J, The Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation . 1999,第11期

机译：左心辅助设备植入后与心脏移植术后晚期心力衰竭患者的功能比较：运动试验中左心辅助设备的使用经验。
4. Plasma Adiponectin Lowering after left Ventricular Assist Device Implantation is Associated with 1-Month Survival in Patients with Advanced Heart Failure [C] . DAmico A., Caruso S., Cabiati M., International Congress on Coronary Artery Disease. . 2013

机译：降低左心室辅助装置植入后降低血浆脂联素与晚期心力衰竭患者的1个月存活相关
5. Optimal Timing of Referral of Heart Failure Patients for Left Ventricular Assist Device Implantation. [D] . Chaplin, Lisa Thomas. 2011

机译：心力衰竭患者左心室辅助装置植入的最佳转诊时间。
6. Adipose Tissue Inflammation and Adiponectin Resistance in Patients with Advanced Heart Failure: Correction after Ventricular Assist Device Implantation [O] . Raffay S. Khan, Tomoko S. Kato, Aalap Chokshi, -1

机译：晚期心力衰竭患者脂肪组织炎症和脂联素抗性：室外辅助装置植入后矫正
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Plasma Adiponectin Lowering after left Ventricular Assist Device Implantation is Associated with 1-Month Survival in Patients with Advanced Heart Failure

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