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首页> 外文会议>International Congress on Cell Biology. >Evaluation of Joannesia princeps aqueous extract anthelmintic activity in naturally infected mice by Syphacia obvelata, Aspiculuris tetraptera and Vampirolepis nana
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Evaluation of Joannesia princeps aqueous extract anthelmintic activity in naturally infected mice by Syphacia obvelata, Aspiculuris tetraptera and Vampirolepis nana

机译：Joannesia princeps含水提取物的评价在天然感染的小鼠中的糖尿病，AspiculurisTetrapla和Vampirolepis Nana天然感染的小鼠中的αmintic活性

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Joannesia princeps Vell. (Fam. Euphorbiaceae), known as ‘’cotieira’’ or andá-a?ú’’ presents medicinalvalue like purgative and is indicated for syphilis manifestations. The root peel tea is used as laxative and the seedtea shows strong anthelmintic activity. In the present work, our goal was to evaluate the therapeutic potential ofJ. princeps aqueous extracts as anthelmintic in naturally infected mice by V. nana, A. tetraptera and S. obvelata.J. princeps leaves were collected at Cabo Frio-RJ and transported to the lab in UFRRJ. Dry leaves weresubmitted to infusion followed by filtration. Final concentration of obtained products was expressed in g/100 ml.J. princeps extracts were applied in young male and female mice weighting around 25g. Applications wereperformed by intragastric administration in the final volume of 0,04mL/g during three consecutive days.Eliminated feces 24h after each application were collected and observed at the stereoscopic microscope. V. nataproglottids were collected and had their wet weight obtained. Eliminated nematodes were identified and counted.After 96h, mice were sacrificed and necropsied, evaluating V. nana segments wet weight and the number ofreminiscent nematodes. Identical proceeding was adopted to control (C) group and with pirantel pamoat/praziquantel reference treatment (protocols approved by CEPEB). Anthelmintic evaluation of the extract wasexpressed in percentage of elimination, and the results showed that J. princeps leaves aqueous extracts (10%) didnot reproduce previous reported pattern described for seed extracts. It was not observed significant difference inpercentage of elimination to any of tested helminthes. J. princeps leaves extract as anthelmintic potentialtherapeutic use analysis still requires pharmacological and clinical assays for its validation.
机译：Joannesia Princeps Vell。 （FAM。Euphorbiaceae），被称为'Cotieira''或Andá-a？ú''呈现出类似的药物等纯化，并显示梅毒表现形式。根剥离茶被用作泻药，种子特性显示出强大的植物活性。在目前的工作中，我们的目标是评估治疗潜力。 Princeps含水提取物作为Anthelmintic在天然感染的小鼠中由V.Nana，A.Tetraptiona和S.Vexelata.j。 Princeps叶子在Cabo Frio-RJ收集并在UFRRJ中运送到实验室。干燥的叶子加入输注，然后过滤。获得产物的最终浓度以G / 100mL.j表示。 Princeps提取物施用于幼小雄性和女性小鼠加重约25g。在连续三天的最终体积中以0.04ml / g的最终体积的胃内施用的应用。在每个申请中收集并在立体显微镜下观察后，将粪便递成24小时。 V.收集NataProptids并获得湿重。鉴定并计数了消除的线虫。96h，处死小鼠并尸检，评价V. NANA段湿重和仲裁线虫数量。采用相同的进展对（c）组和Pirantel酰胺/吡喹酮参考治疗（Cepeb批准的协议）。在消除百分比中对提取物的萃取液评价，结果表明，J.Princeps叶子叶（10％）脱脂液体递容先前报道的种子提取物。没有观察到任何经过测试的蠕虫的消除差异显着差异。 J.Princeps叶子提取物，因为胰岛素潜在的使用分析仍需要药理学和临床测定的验证。

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