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首页> 外文会议>Lateral Thinking: The Evolution of Human Handedness (Workshop) >The protocadherin 11X/Y (PCDH11X/Y) gene pair as determinant of cerebral asymmetry in modern Homo sapiens
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The protocadherin 11X/Y (PCDH11X/Y) gene pair as determinant of cerebral asymmetry in modern Homo sapiens

机译：Protocadherin 11x / Y（PCDH11x / Y）基因对作为现代同性恋中脑不对称的决定因子

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Annett's right-shift theory proposes that human cerebral dominance (the functional and anatomical asymmetry or torque along the antero-posterior axis) and handedness are determined by a single "right-shift" gene. Familial transmission of handedness and specific deviations of cerebral dominance in sex chromosome aneuploidies implicate a locus within an X–Y homologous region of the sex chromosomes. The Xq21.3/Yp11.2 human-specific region of homology includes the protocadherin 11X/Y (PCDH11X/Y) gene pair, which encode cell adhesion molecules subject to accelerated evolution following the separation of the human and chimpanzee lineages six million years ago. PCDH11X and PCDH11Y, differentially regulated by retinoic acid, are highly expressed in the ventricular zone, subplate, and cortical plate of the developing cerebral cortex. Both proteins interact with β-catenin, a protein that plays a role in determining axis formation and regulating cortical size. In this way, the PCDH11X/Y gene pair determines cerebral asymmetry by initiating the right shift in Homo sapiens.
机译：Annett的右转理论提出了人类脑主导地段（函数和解剖学不对称或沿着前后轴线的扭矩）和用法通过单一的“右转”基因确定。性染色体非倍差中脑主导地位的自主传播和特异性偏差均不在性染色体的X-Y同源区域内的基因座。 XQ21.3 / YP11.2人特异性同源区域包括Protocadherin 11x / Y（PCDH11x / Y）基因对，它们在六百万年前分离人和黑猩猩谱系的分离后，编码细胞粘附分子以加速进化的进化。通过视黄酸差异调节的PCDH11x和PCDH11Y在显影脑皮质的心室区域，亚板板和皮质板上高度表达。两种蛋白质与β-连环蛋白相互作用，该蛋白质在确定轴形成和调节皮质尺寸时发挥作用。以这种方式，PCDH11x / Y基因对通过启动Homo Sapiens的右移来决定脑不对称。

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