Research on the chemical material of P~1-stavudine-P~2-acyclovir diphosphate

机译：P〜1-史莱达胺-P〜2-嘧洛洛洛洛洛二维磷酸化学材料的研究

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A novel and efficient method for the preparation of P~1-stavudine-P~2-acyclovir diphosphate has been developed. Acyclovir phosphoropiperidate was prepared from a redox condensation with 2,2'-dithiodianiline/PPh_3. Then, the coupling of phosphoropiperidate with d4T phosphate in the presence of 4,5-dicyanoimidazole as the activator afforded the desired asymmetrical dinucleoside diphosphate in high yield.

机译：已经开发了一种制备P〜Stavudine-P〜2-丙氨酸二磷酸二磷酸二磷酸的新颖和有效的方法。 Acyclovir磷脂酰基由用2,2'-二极管/ PPH_3的氧化还原缩合制备。然后，在4,5-二氰基咪唑的存在下作为活化剂的磷酸酯与D4T磷酸盐的偶联得到的，得到高产的所需的不对称末核苷二磷酸。

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《International Conference on Applied Mechanics and Manufacturing System》|2014年||共4页
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作者
Shan-Shan Gong; Qi Sun;
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中图分类 TH16-53;
关键词
Stavudine; Acyclovir; Activation; Dinucleoside diphosphate; Antiviral;

机译：Stavudine;acyclovir;激活;二核苷二磷酸盐;抗病毒;

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4. Research on the chemical material of P~1-stavudine-P~2-acyclovir diphosphate [C] . Shan-Shan Gong, Qi Sun International Conference on Applied Mechanics and Manufacturing System . 2014

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Research on the chemical material of P~1-stavudine-P~2-acyclovir diphosphate

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