The present study investigates associations of inorganic arsenic (iAs) exposure, blood pressure and structural echocardiographic parameters in a cross sectional study of 173 Mexican children residents in an endemic area who presented concentrations of total speciated arsenic (tAs) in urine ranging from 5.7 to 370 ng As/mL. Results show that children in the highest exposure percentile (75th or <678 μg As/L/year) of cumulative As exposure (SAsE) were related to increased systolic or diastolic Blood Pressure (DBP), had higher Left Ventricular Mass (LVM) and increased Aortic Root Diameter (ARD) than children in the lowest exposure percentile p25th or <307 μg As/L/year). DBP and LVM were not related to iAs metabolites, but ARD were positively associated with the methyl-As (MAs) level in urine. In conclusion, we observed increased diastolic prehypertension and increased concentric left ventricular hypertrophy prevalence in children exposed to iAs.
展开▼
机译：本研究研究了无机砷（IAS）暴露，血压和结构超声心动图参数在173岁墨西哥儿童居民中的横截面研究中的横断面研究，其在尿液中呈现出5.7至370的尿液中的总体规格的砷（TAS）的浓度ng as / ml。结果表明，累积百分比（第75次或<678μgas/ L /年）的儿童累积为暴露（Sase）与收缩期或舒张压（DBP）的增加有关，具有较高的左心室质量（LVM）和增加主动脉根直径（ARD）比曝光百分比最低的儿童为P2504或<307μgsas/ l /年）。 DBP和LVM与IAS代谢物无关，但ARD与尿液中的甲基 - AS（MAS）水平正相关。总之，我们观察到舒张性急性急性血浆增加，并在暴露于IAS的儿童中增加同心左心室肥厚率。
展开▼
