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首页> 外文会议>PSE Meeting on Natural Products in Cancer Prevention and Therapy >Cancer chemopreventive pharmacology of phytochemicals derived from plants of dietary and non-dietary origin: implication for alternative and complementary approaches
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Cancer chemopreventive pharmacology of phytochemicals derived from plants of dietary and non-dietary origin: implication for alternative and complementary approaches

机译：癌症化学预防药物源自膳食和非膳食起源植物的植物化学术：替代和互补方法的含义

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The poor survival statistics of the fatal cancer diseases highlight the need for multiple alternative treatment options. An impressive embodiment of evidence shows that naturally occurring herbal products contain a wide variety of phytochemicals that are regarded as effective cancer protective agents, possessing the ability to retard, block or reverse carcinogenesis. These include dietary agents often termed as nutraceuticals and also the components of non-dietary plants. Many studies in different cell lines, animal models and human epidemiological trials suggest a protective role of a large number of medicinal molecules of herbal origin against different types of cancers. The standard chemotherapeutic regime against cancer faces an unequivocal challenge due to the severity of the side-effects and the post therapeutic management of the disease. Cancer control may therefore benefit from the anti-cancer potential of alternative therapies that may include herbal treatment which nonetheless has been an effective curative strategy reported for a number of diseases since ancient times. In congruence of the above idea, it has been observed that in recent years the demand to utilize alternative approaches to the treatment of cancer is escalating. Additionally, the emergence of resistance to cancer chemotherapy has forced researchers to turn to natural products of herbal and marine origin. Currently, in the armamentarium of anti-cancer pharmaceuticals there are effective plant-derived drugs such as paclitaxel (a complex taxane diterpene isolated from the bark of Taxus brevifolia) which acts as microtubule disruptor. Further there are plant-based dietary agents such as sulphoraphane (an isothiocyanate derived from cruciferous vegetables) and non-dietary agents such as pomiferin (an isofl-avonoid from Madura pomifera) which strongly mimic chemotherapeutic drugs such as vorinostat (suberoylanilidehydroxamic acid) possessing histone diacetylase inhibition activity. In this review we provide a comprehensive outline of the translational potential of plant-based herbal medicine for complementing the current treatment modalities as an adjuvant or alternative therapy for cancer patients.
机译：致命癌症疾病的差的存活统计数据突出了对多种替代治疗方案的需求。证据的令人印象深刻的实施方案表明，天然存在的草药产品含有各种各样的植物化学物质被认为是有效的癌症保护剂，具有延迟，阻滞或逆转致癌的能力。这些包括通常被称为营养制品的膳食剂以及非膳食植物的组分。许多在不同细胞系中的研究，动物模型和人类流行病学试验表明，大量药用草药源性草药突起对不同类型的癌症的保护作用。由于副作用的严重程度和疾病的治疗管理后，标准的化学治疗性制度面临着明确的挑战。因此，癌症控制可能受益于可包括草药治疗的抗癌潜力，这些疗法可能包括草药治疗，这是自古以来的一些疾病报告的有效治疗策略。在上述想法的同时，已经观察到，近年来，利用替代方法治疗癌症的需求正在升级。此外，对癌症化疗的抗性的出现已迫使研究人员转向草药和海洋原产地的天然产物。目前，在抗癌药物的武器中，存在有效的植物衍生的药物，如紫杉醇（从Raxus Brevifolia的树皮中分离的复杂紫杉烷含量），其充当微管破坏器。此外，还存在基于植物的膳食剂，例如磺酰烷（衍生自十字花植物蔬菜的异硫氰酸酯）和非膳食药物，如Pomiferin（来自Madura pomifera的异氟虫），这是强烈模拟的化学治疗药物，如vorinostat（suberoylanilide羟肟酸）具有组蛋白的化学治疗药物二乙酰化酶抑制活性。在本篇综述中，我们提供了基于植物的草药的翻译潜力的全面概述，用于将目前的治疗方式作为癌症患者的辅助或替代治疗。

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