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Methylene blue Photodynamic therapyin rats' wound healing: 21 days follow-up

机译：大鼠伤口愈合的亚甲基蓝色光动力学治疗：21天随访

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The experimental evaluated the photodynamic therapy (PDT) in wound healing. It used 60 male rats, making two circular wounds at each animal. They were treated at 48hs intervals, with methylene blue (MB), low level laser treatment (LLLT) or both, thus resulting in PDT. The wounds were observed 01, 03, 07, 14 and 21 days after and then processed and subjected to HE staining to analyze granulation tissue, necrosis, epithelialization and collagen. After day 1, wounds treated with MB showed necrosis less intense than other groups, and the PDT group showed more intense granulation tissue. At day 3, reepithelialization was absent for half of injuries in the PDT group, and this group was also with lower collagen. However, at day 7, this same group presented reepithelialization more advanced than control group, which did not happen with those treated with MB or LLLT (p = 0.015). The results allow us to conclude that PDT difficulted reepithelization at 7th day and interfered in standard healing. However, when used separately, MB and LLLT interfered significantly compared to the control group, which did not happened to the PDT group. There was no significant difference between the treatment groups in other analysed times.
机译：实验评估了伤口愈合中的光动力治疗（PDT）。它使用了60只雄性大鼠，在每只动物中制作两个圆形伤口。它们以48HS间隔处理，用亚甲基蓝（MB），低水平激光处理（LLLT）或两者，从而导致PDT。观察伤口01,03,07,14和21天，然后处理并进行他染色以分析造粒组织，坏死，上皮化和胶原蛋白。第1天后，用MB处理的伤口显示坏死比其他基团更强烈，并且PDT组显示出更强烈的造粒组织。在第3天，缺席PDT组的一半损伤缺乏重热化，该组也是较低的胶原蛋白。然而，在第7天，同一组呈现重热化比对照组更进一次，这不会发生在MB或LLLT处理的那些（P = 0.015）。结果允许我们得出结论，PDT在第7天难以进行再热版，并干扰标准愈合。然而，当单独使用时，与对照组相比，MB和LLLT干扰，没有发生在PDT组上。在其他分析时间内治疗组之间没有显着差异。

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