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首页> 外文会议>International conference on Soft Materials >Pulling DNA: The Effect of Chain Length on the Mechanical Stability of DNA Chain
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Pulling DNA: The Effect of Chain Length on the Mechanical Stability of DNA Chain

机译：拉动DNA：链长对DNA链机械稳定性的影响

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We have investigated the effect of chain length on the thermal denaturation as well as on mechanical unzipping of double stranded DNA (ds-DNA) molecule. We use a simple nonlinear Peyrard Bishop and Dauxois (PBD) model and calculate the melting temperature as well as the critical force as a function of chain length for different heterogeneous chains. We found that in mechanical unzipping, when a force is applied on an end, there is a length up-to which the effect of applied force sustains. The base pairs beyond this length can not feel the force that is applied on the end. We have studied the chain with other end to be open and with the other end to be restricted. By comparing the force required to unzip the chain in these two cases, we found a critical length above which the entropy contribution from the end is not significant to change the duplex state of the chain. For shorter chain, we found that the entropic forces due to open end have significant contribution to change the duplex state of DNA to single strand state of DNA chain.
机译：我们研究了链长对热变性的影响以及双链DNA（DS-DNA）分子的机械解压缩。我们使用简单的非线性Peyrard主教和Dauxois（PBD）模型，并根据不同异质链的链长的函数计算熔化温度以及临界力。我们发现，在机械解压缩中，当在最后施加力时，存在施加力维持的效果的长度。超出此长度的碱基对不能感觉到最后施加的力。我们已经研究了其他端的链条才能打开，另一端受到限制。通过比较在这两种情况下解压缩链条所需的力，我们发现从结束的熵贡献改变链的双工状态并不重要。对于较短的链条，我们发现由于开口的熵力与将DNA双相状态改变为单链状态的DNA链具有显着贡献。

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