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首页> 外文会议>Conference of the American College of Veterinary Internal Medicine >Why Foals Don't Gallop In Utero: Studies in Transitions of Fetal Consciousness with Implications for NeonatalHealth
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Why Foals Don't Gallop In Utero: Studies in Transitions of Fetal Consciousness with Implications for NeonatalHealth

机译：为什么驹在子宫中没有疾病：胎儿意识过渡的研究，对新生儿健康的影响

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A syndrome termed neonatal maladjustment syndrome (NMS) in the UK, and more recently as hypoxic ischemic encephalopathy (HIE) or perinatal asphyxia in the USA, is characterized by neurological and behavioral abnormalities that develop in the early neonatal period in foals. Other terms used include "dummy foals", wanderers, and barkers. The literature suggests that this is one of the most common diseases affecting newborn foals. The cause of NMS has been attributed by some to pre-, intra- or postnatalhypoxia leading to neuronal cellular energy failure and death. Clinical signs have been stated to be consistent with brain hypoxia and include alterations in the state of consciousness from mild obtundation to stuporous to comatose; abnormal behavior such as lack of affinity for the mare, not nursing, vocalization, and wandering; blindness; and paroxysmal activity such as paddling and seizures. Histopathological evidence of cerebral hemorrhage and hypoxia has been detected in some severely affected foals in the mid 1970's prior to the creation of the discipline of neonatal intensive critical care. However, many foals in recent studies do not have histological evidence of hypoxia, edema or hemorrhage. Additionally, unlike hypoxic human infants that goon to have residual neurologic deficits7, 80% foals with NMS recover well and fully in the absence of any specific therapy other than supportive measures8. These disparities have led the Equine and Comparative Neurology Research group at UC Davis to question the hypoxia hypothesis and search for an alternative explanation with a focus on the transition of fetal consciousness at birth.
机译：在英国的新生儿患病综合征（NMS）中称为新生儿患者综合征（NMS），并且在美国的缺氧缺血性脑病（HIE）或围产期窒息的特征在于发泡早期新生儿时期的神经系统和行为异常。使用的其他术语包括“伪马驹”，流浪者和Barkers。文献表明这是影响新生儿最常见的疾病之一。 NMS的原因已被一些导致神经元细胞能量失败和死亡的预期，或后产卵中的某些原因。已经表明临床迹象与脑缺氧一致，包括从轻度抗冲求的意识状态改变到昏昏欲睡;异常行为，如母马缺乏亲和力，而不是护理，发声和徘徊;失明;和阵发性活动，如划桨和癫痫发作。在1970年年中，在创建新生儿密集型关怀学科之前，在一些严重影响的粪便中检测到脑出血和缺氧的组织病理学证据。然而，最近的研究中许多脱氧层没有缺氧，水肿或出血的组织学证据。此外，与缺氧的人婴儿不同，GoON具有残留的神经系统缺陷7,80％的小鼠，NMS恢复良好，并且在没有支持措施以外的任何特异性治疗的情况下完全恢复。这些差异导致了UC戴维斯的马和比较神经内科研究组来质疑缺氧假设，并在出生时关注胎儿意识的转型来寻找替代解释。

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