Insulin-secreting tumors, more commonly known as insulinomas (INS) originate from endocrine cells from the islets of Langerhans in the pancreas. INS are uncommon in dogs and very rare in cats. Primary canine INS are commonly solitary tumors and theirdiameter is usually smaller than 2.5 cm. Most INS are located in the left or right pancreatic lobe. In general canine INS are considered to be malignant in more than 95% of cases, because they almost always tend to metastasize, even though they may lackhistological criteria of malignancy. INS hypersecrete insulin and cause an increased insulin concentration in the blood. Normally when blood glucose concentrations decrease, insulin secretion is inhibited. Neoplastic □□cells are less sensitive to the negative feedback of low blood glucose concentrations and secrete inappropriately high amounts of insulin despite declining blood glucose concentrations resulting in a profound hypoglycemia.
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机译：胰岛素分泌的肿瘤，更常见的是胰岛素瘤（INS）源自来自胰腺中的胰岛胰岛的内分泌细胞。在狗和猫中非常罕见，INS罕见。原发性犬INS通常是孤零性的肿瘤，它们的其Diameter通常小于2.5厘米。大多数INS位于左侧或右胰腺。在一般的犬内被认为是超过95％的病例恶性，因为它们几乎总是倾向于转移，即使它们可能缺乏恶性肿瘤的标准。 INS Hypersecrete胰岛素并导致血液中胰岛素浓度增加。通常，当血糖浓度降低时，抑制胰岛素分泌。肿瘤□□细胞对低血糖浓度的负反馈不太敏感，并且尽管血糖浓度下降导致血糖浓度下降，但仍有不恰当地高量的胰岛素。
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