Isolation and identification of burn wound superbugs by molecular technique and their susceptibility to silver nanoparticles

机译：分子技术分离与鉴定烧伤伤口超前粒子的银纳米粒子敏感性

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Burn wound is a global problem affecting millions of people. It is the major cause of mortality and morbidity. This study was aimed to isolate and identify the wound isolates by 16S rRNA and to assess their susceptibility to antibiotics and silver nanoparticles. Silver nanoparticles were synthesized using aqueous extract of A.indica. The silver nanoparticles were characterized by FESEM, XRD, FTIR and DSC. Antibacterial susceptibility of the isolates was assessed by well diffusion method. The wound isolates were identified as S. aureus and E.coli. Both isolates were resistant to β lactum antibiotics, aminoglycoside, quinolones and macrolides. The inhibition zone exhibited by all antibiotics against both organisms was less than 5 mm. The size of silver nanoparticles were recorded as 55 nm. XRD confirmed the crystalline nature of the nanoparticles. TGA and DSC of silver nanoparticles showed the loss of weight and the melting point of silver nanoparticles was recorded at 871.3°C. Silver nano particles inhibited S.aureus and E.coli with an inhibition zone of 27 mm and 32 mm respectively. Therefore the study demonstrated that only silver containing dressings can be used in burn wounds infected by multi drug resistant super bugs.

机译：烧伤创面是影响数以百万计的人一个全球性问题。它是死亡率和发病率的主要原因。本研究旨在孤立和的16S rRNA鉴定伤口分离，并评估其对抗生素的耐药和银纳米粒子。银纳米颗粒，使用A.indica的水性提取物合成。通过FESEM，XRD，FTIR和DSC的银纳米颗粒进行了表征。分离株的抗菌敏感性通过阱扩散方法评定。伤口分离株被鉴定为金黄色葡萄球菌和大肠杆菌。两个分离株耐内酰胺β抗生素，氨基糖苷类，喹诺酮类和大环内酯类。通过针对两种生物体所有抗生素表现出的抑制区为小于5mm。银纳米颗粒的尺寸被记录为55纳米。 XRD证实纳米颗粒的结晶性质。 TGA和银纳米颗粒的DSC显示的重量损失和银纳米粒子被记录了在871.3℃的熔点。的银纳米颗粒的金黄色葡萄球菌的抑制和大肠杆菌为27毫米，分别为32毫米的抑制圈。因此，研究表明，只有含银敷料可以通过多重耐药性超级细菌感染的烧伤创面使用。

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《International Conference on Advances in Materials and Manufacturing Applications》|2018年|698-1407 p.|共10页
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R Mala; A S Ruby Celsia;
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中图分类工程材料学;
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3. Comparison of efficacy of silver-nanoparticle gel, nano-silver-foam and collagen dressings in treatment of partial thickness burn wounds [J] . Erring Miying, Gaba Sunil, Mohsina Subair, Burns: Including Thermal Injury . 2019,第8期

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4. Isolation and identification of burn wound superbugs by molecular technique and their susceptibility to silver nanoparticles [C] . R Mala, A S Ruby Celsia International Conference on Advances in Materials and Manufacturing Applications . 2018

机译：分子技术分离与鉴定烧伤伤口超前粒子的银纳米粒子敏感性
5. Nanoparticle toxicity and molecular mechanisms in fish: A case study with silver nanoparticles [D] . Gao, Jiejun 2016

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6. Clinical Utility of PNA-FISH for Burn Wound Diagnostics: A Noninvasive Culture-Independent Technique for Rapid Identification of Pathogenic Organisms in Burn Wounds [O] . Alan J Weaver Jr, Kenneth S Brandenburg, Fatemeh Sanjar, -1

机译：PNA-FISH在烧伤创面诊断中的临床实用性：一种无创与培养无关的技术可快速鉴定烧伤创面中的病原体
7. Clinical Utility of PNA-FISH for Burn Wound Diagnostics: A Noninvasive, Culture-Independent Technique for Rapid Identification of Pathogenic Organisms in Burn Wounds [O] . Alan J Weaver, Kenneth S Brandenburg, Fatemeh Sanjar, 2019

机译：烧伤伤口诊断PNA鱼的临床效用：一种非侵入性，文化无关的技术，用于快速鉴定烧伤伤口的病原体

Isolation and identification of burn wound superbugs by molecular technique and their susceptibility to silver nanoparticles

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