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Bio-Mechanically Active Ceramic-Polymeric Hybrid Scaffolds for Tissue Engineering

机译：用于组织工程的生物机械活性陶瓷聚合杂交支架

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The research develops and tests new hybrid biomimetic materials that work as mechanically stimulating "scaffolds" to promote early regeneration in implanted bone healing phases. A biomimetic nanostructured osteo-conductive material coated apparatus is presented. A bio-inspired approach to materials and template growth of hybrid networks using self-assembled hybrid organic-inorganic interfaces is finalized to extend the use of hybrids in the medical field. Combined in vivo, in vitro and computer aided simulations have been carried out. A new experimental methodology for the identification of design criteria for new innovative prosthetic implant systems is presented. The new implant design minimizes the invasiveness of treatments while improving implant functional integration. A new bioactive ceramic-polymeric hybrid material was used to modify odontostomatological Titanium implants in order to promote early fixation, biomechanical stimulation for improved scaffold mineralization and ossification. It is hybrid ceramic-polymeric nano-composites based on Hydroxyl-Ethyl-Methacrylate polymer (pHEMA) filled with nanosilica particles that have shown biomimetic characteristics. This material swells in presence of aqueous physiological solution leading to the achievement of two biomechanical functions: prosthesis early fixation after and bone growth stimulation. Such multidisciplinary approach explores novel ideas in modelling, design and fabrication of new nanostructured biomaterials with enhanced functionality and improved interaction with OB cells.
机译：该研究开发和测试了新的混合仿真材料，该材料作为机械刺激“支架”，以促进植入骨愈合阶段的早期再生。提出了一种仿真纳米结构的骨导电材料涂覆装置。最终确定了使用自组装杂种有机无机界面的混合网络的材料和模板生长的生物启发方法，以延长医疗领域中的杂种的使用。结合体内，体外和计算机辅助模拟已经进行。提出了一种新的新型创新假体植入系统设计标准的新实验方法。新的植入物设计最小化治疗的侵袭性，同时改善植入物功能集成。新的生物活性陶瓷聚合杂化材料用于改性Odontostomatology钛植入物，以促进早期固定，生物力学刺激，改善的支架矿化和骨化。它是基于填充有纳米硅藻颗粒的羟基 - 乙基 - 甲基丙烯酸酯聚合物（PHEMA）的杂种陶瓷聚合物纳米复合材料，所述纳米硅烷颗粒具有显示为仿生特性的纳米二硅颗粒。该物质在水性生理溶液存在下溶胀，导致两种生物力学功能的成就：假体早期固定后和骨生长刺激。这种多学科方法探讨了具有增强功能的新型纳米结构生物材料的建模，设计和制备的新颖思想，并改善了与OB细胞的相互作用。

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