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Analysis of Codon Bias on Clostridium Perfringens Dell Genome

机译：梭菌强度沉胶基因组密码子偏差分析

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Clostridium perfringens is a conditional pathogen, which widely exists in the nature water, soil, intestinal tract, and serious threat to public health and safety. In this study, the codon usage of Clostridium perfringens was examined. CDS sequences of 2744 high confidence protein coding genes were selected from Clostridium perfringens Genome Database. Their GC content of these genes ranged from 14.7% to 41.9%, with the average of 29.9% for whole genome. The frequency of G or C in the third position of synonymous codon was 25.6%, which was lower than that of A or T. The effective number of codon(ENC) of Clostridium perfringens genome ranged from 26.9 to 61.0, with the average of 39.9. Clostridium perfringens prefer codons ending in A/T. The ENC values of each gene significantly positive correlated with its C3s, G3s, GC3s and GC content (r=0.674, 0.738, 0.780 and 0.368, respectively, p<0.01). However, ENC showed significant negative correlations with T3s, A3s and CAI (r=-0.668, -0.688 and -0.255, respectively, p<0.01). A total of 27 optimal codons were found from Clostridium perfringens genome, all of which the third position of synonymous codon was A or T.
机译：梭菌菌素是一种有条件的病原体，其在自然水，土壤，肠道和对公共卫生和安全的严重威胁中广泛存在。在这项研究中，检查了梭菌的密码子使用。 2744的CDS序列高置信蛋白编码基因选自梭菌基因组数据库。它们的GC含量为这些基因的14.7％至41.9％，整个基因组的平均值为29.9％。同义密码子的第三位的G或C的频率为25.6％，低于A或T.的有效数量的蛋白酶基因组的密码子（ENC）范围为26.9至61.0，平均值为39.9 。 Clostridium perfringens更喜欢以/ t结尾的密码子。每个基因的ENC值与其C3S，G3S，GC3和GC含量显着呈正相关（r = 0.674,0.738,0.780和0.368，P <0.01）。然而，ENC显示出与T3S，A3S和CAI（R = -0.668，-0.688和-0.255分别的显着的负相关，P <0.01）。从梭菌基因组中发现了27个最佳密码子，所有这些都是同义密码子的第三位是A或T.

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