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Transcriptome Reveals That Genic SNPs Contributes to Heterosis in Cattle

机译：转录组揭示了基因Snps在牛中有助于杂种优势

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Heterosis is a powerful and valuable tool for commercial beef producers, especially cow calf operations. Despite the importance of heterosis, and its extensive genetic analysis, little understanding exists of its molecular basis. We applied RNA-Seq technology to assess transcriptome-wide allele-specific gene expression (ASGE) in the hybrid genetic background at economic traits of offspring and maternal. 120 genes of these were different expression among three individuals in common. Among these genes, we found that three genes involved in melanogenesis pathway, including MC1R, DCT and TYR. In addition six of the altered expression genes were related to arachidonic acid (AA) metabolism, such as PTGS1, PTGIS, PTGR1, ALOX12B, ALOX15B and EPHX2. We find that coat color traits could be utilized to check the analysis pipeline for heterosis studies. Results from this study indicate that the parental alleles have un-equivalent functions in the hybrid, which may have an impact on heterosis.
机译：杂种优势是商业牛肉生产商的强大而有价值的工具，特别是牛犊业务。尽管杂种优势的重要性以及其广泛的遗传分析，但其分子基础存在很少的理解。我们应用RNA-SEQ技术评估在后代和母体经济特征的杂交遗传背景中的转录组宽的等位基因特异性基因表达（Asge）。其中120个基因在共同的三个人中是不同的表达。在这些基因中，我们发现三种基因参与素质生成途径，包括MC1R，DCT和Tyr。此外，还有六种改变的表达基因与花生酸（AA）代谢有关，例如PTGS1，PTGI，PTGR1，Alox12b，Alox15b和Ephx2。我们发现可用于检查涂层颜色性状以检查分析管道是否有杂种优势研究。本研究的结果表明，父母等位基因在杂交中具有不等同的功能，这可能对杂种优势产生影响。

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