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首页> 外文会议>International Conference on Biological Sciences and Technology >Preparation and Properties of Crosslinked Silk Fibroin Film
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Preparation and Properties of Crosslinked Silk Fibroin Film

机译：交联丝纤维素膜的制备与性能

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摘要

In this study, regenerated silk fibroin (SF) film was prepared by using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) as cross-linking agent and N-hydroxysuccinimide (NHS), 2-morpholinoethanesulfonic acid (MES) as assistant agent. To evaluate the effects of EDC cross-linking agent on SF film performence, the water resistance, condensed structure, tensile strength, elongation, Young's modulus of crosslinked film were examined and analyzed. The water solubility and Young's modulus of the film with 20 wt% EDC decreased remarkably, while film elongation increased. Further, the FTIR, Raman spectra and X-Ray Diffraction (XRD) were employed to investigate the molecule conformation transition and insight the mechanism of the crosslinking. The results demonstrated that crosslinked film contained more silk I when ～20 wt% EDC (weight ratio to SF) was added. When more than 20 wt%, the content of silk I decreased remarkably while that of silk II increased in the SF film. Due to the reaction of EDC, carboxylic acid groups and amino groups were bound by amide bond formation between the SF molecules. The NHS plays an activation of -OH group; the MES creates a faintly acid condition to be beneficial for the cross-link reaction. This study provided an important method to prepare insoluble SF materials and promoted application of the SF materials.
机译：在该研究中，通过使用1-乙基-3-（3-二甲基氨基丙基）碳二亚胺（EDC）作为交联剂和N-羟基琥珀酰亚胺（NHS），2-羟基乙烯磺酸（MES）制备再生丝素蛋白（SF）膜（MES ）作为助剂代理人。为了评估EDC交联剂对SF膜效果的影响，检查并分析了耐水性，缩合结构，拉伸强度，伸长率，杨氏模量。 20wt％EDC的薄膜的水溶性和杨氏模量显着降低，而薄膜伸长率增加。此外，采用FTIR，拉曼光谱和X射线衍射（XRD）来研究分子构象转变和交联机制的洞察力。结果表明，当加入20wt％的EDC（重量比）时，交联膜更具丝绸I。当超过20wt％时，丝绸的含量显着下降，而丝绸II的含量在SF膜上增加。由于EDC的反应，羧酸基团和氨基通过SF分子之间的酰胺键形成而结合。 NHS发挥-OH组的激活; MES产生微弱的酸性条件，对交联反应有益。本研究提供了制备不溶性SF材料并促进SF材料的重要方法。

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