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首页> 外文会议>International Conference on Biological Sciences and Technology >The Research on the Mechanism of Antioxidative and Growth-Promoting Effects of Polyphenols from the Involucres of Castanea Mollissima Blume on IEC-6 Cells
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The Research on the Mechanism of Antioxidative and Growth-Promoting Effects of Polyphenols from the Involucres of Castanea Mollissima Blume on IEC-6 Cells

机译：从IEC-6细胞对Castanea Mollissima Blume中的抗氧化和生长促进抗氧化和生长促进作用的研究

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摘要

The aim of the paper was to study the effects of Polyphenolic extract from involucres of Castanea mollissima Blume (PICB) on IEC-6 cell proliferation and growth and antioxidant status. The IEC-6 heat stress model was established and IEC-6 cells of control group and heat stress group were treated with 80μg/ml PICB. HSP70 ODC EGF, EGFR, SOD mRNA transcription and protein expression of IEC-6 cells were detected using RT-PCR and Western blot. The results showed that PICB concentrations had no significant effect (P > 0.05) on mRNA and protein expression of IEC-6 in normal temperature. Under heat stress conditions, HSP70, ODC, EGF, EGFR, SOD mRNA transcription and protein expression of PICB group were higher than the control group (P<0.05). In conclusion, PICB could up-regulate HSP70, ODC, EGF, EGFR, SOD mRNA and protein expression of heat stressed IEC-6 cell, showing the mechanism of its anti-oxidative and growth-promoting function.
机译：本文的目的是研究多酚提取物从Castanea Mollissima Blume（PICB）中的多酚提取物对IEC-6细胞增殖和生长和抗氧化状态的影响。建立了IEC-6热应激模型，并用80μg/ ml皮法处理对照组和热应激组的IEC-6细胞。使用RT-PCR和Western印迹检测HSP70 ODC EGF，EGFR，SOD mRNA转录和IEC-6细胞的蛋白表达。结果表明，在正常温度下，皮布浓度对IEC-6的mRNA和蛋白质表达没有显着效果（p> 0.05）。在热应激条件下，HSP70，ODC，EGF，EGFR，SOD mRNA转录和PICB组的蛋白表达高于对照组（P <0.05）。总之，PICB可以上调HSP70，ODC，EGF，EGFR，SOD mRNA和热应激IEC-6细胞的蛋白表达，显示其抗氧化和生长促进功能的机理。

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