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首页> 外文会议>SPIE Conference on Biophotonics >Noninvasive in vivo plasma volume and hematocrit in humans: observing long-term baseline behavior to establish homeostasis for intravascular volume and composition
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Noninvasive in vivo plasma volume and hematocrit in humans: observing long-term baseline behavior to establish homeostasis for intravascular volume and composition

机译：人类体内血浆体积和血细胞比容的非侵入性：观察长期基线行为，以建立血管内体积和组成的稳态

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A new device incorporating a new algorithm and measurement process allows simultaneous noninvasive in vivo monitoring of intravascular plasma volume and red blood cell volume. The purely optical technique involves probing fingertip skin with near infrared laser light and collecting the wavelength shifted light, that is, the inelastic emission (IE) which includes the unresolved Raman and fluorescence, and the un-shifted emission, that is, the elastic emission (EE) which includes both the Rayleigh and Mie scattered light. Our excitation and detection geometry is designed so that from these two simultaneous measurements we can calculate two parameters within the single scattering regime using radiation transfer theory, the intravascular plasma volume fraction and the red blood cell volume fraction. Previously calibrated against a gold standard FDA approved device, 2 hour monitoring sessions on three separate occasions over a three week span for a specific, motionless, and mostly sleeping individual produced 3 records containing a total of 5706 paired measurements of hematocrit and plasma volume. The average over the three runs, relative to the initial plasma volume taken as 100%, of the plasma volume±1σ was 97.56±0.55 or 0.56%.For the same three runs, the average relative hematocrit (Hct), referenced to an assumed initial value of 28.35 was 29.37±0.12 or stable to ±0.4%.We observe local deterministic circulation effects apparently associated with the pressure applied by the finger probe as well as longer timescale behavior due to normal ebb and flow of internal fluids due to posture changes and tilt table induced gravity gradients.
机译：结合了新的算法和测量过程的新设备允许在体内同时无创监测血管内血浆体积和红细胞体积。纯粹的光学技术涉及探测指尖皮肤用近红外激光光并收集波长移位的光，即，无弹性发射（IE），其包括未解决的拉曼和荧光，和未偏移发射，即，弹性发射（EE），其包括两个瑞利和米氏散射光。我们的激发和检测的几何形状被设计成使得来自这两个同时测量，我们可以利用辐射传输理论中，血管内血浆体积分数和红血细胞的体积分数的单一散射状态内计算两个参数。先前校准针对金标准FDA批准装置; 2小时监测在三个不同场合会话超过三周跨度为一个特定的，不动，而且大多睡眠者产生的3个记录含有总共血细胞比容和血浆体积的5706次成对测量。在三次运行过的平均值，相对于初始血浆体积取为100％时，等离子体体积±1σ为97.56±0.55 0.56％。对于相同的三次运行，平均相对血细胞比容（HCT），参考一个假定的的28.35初始值为29.37±0.12或稳定到±0.4％。我们观察由于姿势变化显然与压力相关联的施加通过手指探针以及更长的时间尺度行为由于正常的低潮和内部流体流动的地方确定性循环效应和倾斜表诱导重力梯度。

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