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首页> 外文会议>SPIE Conference on Biophotonics >Comparison of UVB and UVC irradiation disinfection efficacies on Pseudomonas Aeruginosa (P. aeruginosa) biofilm
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Comparison of UVB and UVC irradiation disinfection efficacies on Pseudomonas Aeruginosa (P. aeruginosa) biofilm

机译：铜绿假单胞菌（P. Aerginosa）生物膜对UVB和UVC辐照消毒生物效果的比较

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Disinfection routines are important in all clinical applications. The uprising problem of antibiotic resistance has driven major research efforts towards alternative disinfection approaches, involving light-based solutions. Pseudomonas aeruginosa (P. aeruginosa) is a common bacterium that can cause skin, soft tissue, lungs, kidney and urinary tract infections. Moreover, it can be found on and in medical equipment causing often cross infections in hospitals. The objective of this study was to test the efficiency, of two different light-based disinfection treatments, namely UVB and UVC irradiation, on P. aeruginosa biofilms at different growth stages. In our experiments a new type of UV light emitting diodes (LEDs) were used to deliver UV irradiation on the biofilms, in the UVB (296nm) and UVC (266nm) region. The killing rate was studied as a function of dose for 24h grown biofilms. The dose was ramped from 72J/m2 to 10000J/m2. It was shown that UVB irradiation was more effective than UVC irradiation in inactivating P. aeruginosa biofilms. No colony forming units (CFU) were observed for the UVB treated biofilms when the dose was 10000 J/m2 (CFU in control sample: 7.5 x 10~4). UVB irradiation at a dose of 20000J/m2 on mature biofilms (72h grown) resulted in a 3.9 log killing efficacy. The fact that the wavelength of 296nm exists in daylight and has such disinfection ability on biofilms gives new perspectives for applications within disinfection at hospitals.
机译：消毒惯例在所有临床应用中都很重要。抗生素抗性的起义问题推动了涉及基于轻型解决方案的替代消毒方法的主要研究努力。假单胞菌铜绿假单胞菌（P. Aerginosa）是一种可引起皮肤，软组织，肺，肾和尿路感染的常见细菌。此外，它可以在医疗设备上找到，导致医院的过度感染。本研究的目的是测试不同生长阶段的P. Aeruginosa生物膜的两种不同轻基的消毒处理，即UVB和UVC辐射的效率。在我们的实验中，使用一种新型的UV发光二极管（LED）来在UVB（296nm）和UVC（266nm）区域中对生物膜进行紫外线辐射。研究了杀戮率作为24h种生物膜的剂量的函数。将剂量从72J / m 2升至10000J / m 2。结果表明，UVB辐射比灭活P.铜绿假单胞菌的UVC辐射更有效。当剂量为10000J / m 2时，没有观察到UVB处理的生物膜的菌落形成单元（CFU）（对照样品中的CFU：7.5×10〜4）。在成熟生物膜（72h种植）上以20000J / m 2的剂量的UVB辐射导致3.9次杀伤效果。日光中产生296nm的波长的事实，并且在生物膜上具有这种消毒能力，为医院消毒中的应用提供了新的视角。

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