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首页> 外文会议>International Baltic Conference of Engineering Materials and Tribology >Bovine Serum Albumin Adsorption onto Hydroxyapatite and Biphasic Calcium Phosphate Ceramic Granules
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Bovine Serum Albumin Adsorption onto Hydroxyapatite and Biphasic Calcium Phosphate Ceramic Granules

机译：牛血清白蛋白吸附在羟基磷灰石和双相磷酸钙陶瓷颗粒上

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Calcium phosphate ceramics are one of the most studied biomaterials for bone substitution and regeneration. Bioactivity is one of the most important properties for these materials, and it can be evaluated by adsorption of proteins and by hydroxyapatite formation on the surface in simulated body fluid (SBF). The aim of this work was to evaluate the bioactivity of ceramic granules with various hydroxyapatite (HAp) and beta tricalcium phosphate (β-TCP) ratios by adsorption of bovine serum albumin (BSA) in SBF and phosphate saline buffer (PBS) solution. The highest adsorption capacity in both solutions was observed for biphasic calcium phosphate sample with HAp/β-TCP ratio 50/50 but the lowest - for sample 10/90. The adsorption capacity of all samples was more than 2 times higher in SBF media than in PBS. The possibility of hydroxyapatite formation was evaluated by changes of Ca~(2+) concentration in SBF. After 5 days of incubation at 37 °C all samples showed a decrease in Ca ~~(2+) concentration.
机译：磷酸钙陶瓷是用于骨置换和再生研究最多的生物材料中的一个。生物活性是对这些材料的最重要的性质之一，并且它可以通过蛋白质的吸附，并通过在模拟体液（SBF）的表面上形成羟基磷灰石进行评价。这项工作的目的是评价与各种羟基磷灰石（HAP）和β-磷酸三钙（β-TCP）通过在SBF牛血清白蛋白（BSA）和磷酸盐缓冲液（PBS）溶液的吸附率的陶瓷颗粒的生物活性。观察到在这两种解决方案的最高吸附容量与羟基磷灰石/β-TCP的比例50/50但最低双相磷酸钙样品 - 样品10/90。所有样品的吸附容量为在SBF媒体比在PBS高出2倍。羟基磷灰石形成的可能性是由钙〜（2+）在SBF浓度的变化进行评价。后在37℃下培养5天后的所有样品显示在钙的减少~~（2+）浓度。

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