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首页> 外文会议>Conference on optical tomography and spectroscopy of tissue XII >Induced and spontaneous hemodynamic oscillations in cerebral and extracerebral tissue for coherent hemodynamics spectroscopy
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Induced and spontaneous hemodynamic oscillations in cerebral and extracerebral tissue for coherent hemodynamics spectroscopy

机译：相干血液动力学光谱诱导和自发性血液动力学振动脑和脑骨组织

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We report preliminary results of a study for investigating the spatial homogeneity of induced and spontaneous oscillations in the concentration of oxyhemoglobin on the scalp/skull layer of two human subjects. Hemodynamic oscillations were induced by modulation of arterial blood pressure, which triggers the cerebral autoregulation mechanism. Induced hemodynamic oscillations are used in coherent hemodynamics spectroscopy to derive physiological parameters of interest for medical diagnostics. For example, our dedicated mathematical model translates typical near-infrared spectroscopy observables, like the amplitude and phase relationship of the oscillations of oxy- and deoxyhemoglobin concentrations into capillary and venous blood transit times, cutoff frequency of the autoregulation process, and other parameters related to microvascular blood volume. In this study, we focused on the phase relationship between the oscillations of oxyhemoglobin concentrations in three optical channels, two of which feature a short (5 mm) source-detector separation (sampling the scalp/skull only) and the third one features a long (30 mm) source-detector separation (sampling both extracerebral and cerebral tissues). The two main goals of the study were: a) to compare the coherence of induced and spontaneous oscillations; b) to assess if induced and spontaneous oscillations may be assumed to be uniform in the extracerebral layer. This was assessed by studying the phase relationship of oscillations in oxyhemoglobin concentration at the two short source-detector separations. About point a) we verified that induced oscillations have a higher incidence of coherence than spontaneous oscillations: 74% for induced oscillations, and 30% for spontaneous oscillations. About point b) the results show an overall trend for both spontaneous and induced oscillations to be homogeneous or "quasi-homogeneous" in the extracerebral tissue; however, we observed cases where a significant non-zero phase difference was measured, indicating spatial heterogeneity. We propose a method for taking into account the possible inhomogeneous behavior of the oscillations in the scalp/skull in order to increase the accuracy of measurements of cerebral hemodynamic oscillations.
机译：我们报告了研究两种人对象的头皮/颅骨层浓度浓度和自发振荡的研究的初步结果。通过调节动脉血压诱导血流动力学振荡，从而触发脑自身调节机制。诱导的血流动力学振荡用于相干血流动力学光谱，从而导出医疗诊断感兴趣的生理参数。例如，我们的专用数学模型转化了典型的近红外光谱可观察，如氧化氧和脱氧血红蛋白浓度振荡的振幅和相位关系进入毛细管和静脉血管血管血管血管血管速度，自动调节过程的截止频率以及与之相关的其他参数微血管血容量。在这项研究中，我们专注于三个光学通道中的氧血红蛋白浓度振荡之间的相位关系，其中两个具有短（5 mm）源检测器分离（仅取样头皮/颅骨）和第三个功能长（30 mm）源检测器分离（取样骨干网和脑组织）。该研究的两个主要目标是：a）比较诱导和自发振荡的一致性; b）评估是否可以假设诱导和自发振荡在脑层中均匀。通过在两个短源检测器分离中研究氧血红蛋白浓度振荡的相位关系来评估这一点。关于点A）我们验证了诱导的振荡的相干发生率较高，比自发振荡的发生率：诱导振荡的74％，自发振荡的30％。关于点B）结果表明，自发性和诱导振荡的总体趋势是在骨组织中均匀或“准均匀”;然而，我们观察到测量显着的非零相差异的情况，表明空间异质性。我们提出了一种考虑到头皮/颅骨中振荡的可能不均匀行为的方法，以提高脑血流动力学振荡测量的准确性。

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