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首页> 外文期刊>NeuroImage >Phase-amplitude investigation of spontaneous low-frequency oscillations of cerebral hemodynamics with near-infrared spectroscopy: A sleep study in human subjects
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Phase-amplitude investigation of spontaneous low-frequency oscillations of cerebral hemodynamics with near-infrared spectroscopy: A sleep study in human subjects

机译：近红外光谱法研究自发性血液动力学自发性低频振荡的相振幅：人体研究

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摘要

We have investigated the amplitude and phase of spontaneous low-frequency oscillations (LFOs) of the cerebral deoxy- and oxy-hemoglobin concentrations ([Hb] and [HbO]) in a human sleep study using near-infrared spectroscopy (NIRS). Amplitude and phase analysis was based on the analytic signal method, and phasor algebra was used to decompose measured [Hb] and [HbO] oscillations into cerebral blood volume (CBV) and flow velocity (CBFV) oscillations. We have found a greater phase lead of [Hb] vs. [HbO] LFOs during non-REM sleep with respect to the awake and REM sleep states (maximum increase in [Hb] phase lead: ~. π/2). Furthermore, during non-REM sleep, the amplitudes of [Hb] and [HbO] LFOs are suppressed with respect to the awake and REM sleep states (maximum amplitude decrease: 87%). The associated cerebral blood volume and flow velocity oscillations are found to maintain their relative phase difference during sleep, whereas their amplitudes are attenuated during non-REM sleep. These results show the potential of phase-amplitude analysis of [Hb] and [HbO] oscillations measured by NIRS in the investigation of hemodynamics associated with cerebral physiology, activation, and pathological conditions.
机译：我们已经在人类睡眠研究中使用近红外光谱（NIRS）研究了大脑脱氧和氧合血红蛋白浓度（[Hb]和[HbO]）的自发低频振荡（LFO）的幅度和相位。振幅和相位分析基于解析信号方法，并且相量代数用于将测得的[Hb]和[HbO]振荡分解为脑血容量（CBV）和流速（CBFV）振荡。我们发现，相对于清醒和REM睡眠状态，非REM睡眠期间[Hb] LFO比[HbO] LFO的相位超前（[Hb]相位超前的最大增加：〜.π/ 2）。此外，在非REM睡眠期间，相对于清醒和REM睡眠状态，[Hb]和[HbO] LFO的幅度受到抑制（最大幅度降低：87％）。发现相关的脑血容量和流速振荡在睡眠期间保持它们的相对相位差，而在非快速眼动睡眠期间它们的振幅被衰减。这些结果显示了通过NIRS测量[Hb]和[HbO]振荡的相幅分析在研究与脑生理，激活和病理状况相关的血液动力学方面的潜力。

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