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首页> 外文会议>Conference on optical tomography and spectroscopy of tissue XII >The complex evaluation of tumor oxygen state and vasculature during preoperative chemotherapy in patients with breast cancer
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The complex evaluation of tumor oxygen state and vasculature during preoperative chemotherapy in patients with breast cancer

机译：患有乳腺癌术前化疗期间肿瘤氧状态和脉管系统的复杂评价

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Effective breast cancer treatment requires the assessment of metabolic changes of tumor tissue during chemo- and hormonotherapy for prediction tumor response. Evaluation of the dynamics of tumor oxygen state (by diffuse optical spectroscopy imaging) and tumor vasculature (by ultrasound investigation in power Doppler mode) was performed before treatment beginning and before the second cycle of chemotherapy in 16 patients who received preoperative chemotherapy. Changes of these indicators were compared then with tumor pathologic response. Breast tumors demonstrated different dynamics of tumor oxygenation depending on the changes of tumor tissue. The increase of the tumor oxygenation after the first cycle of chemotherapy was observed in five of six patients with grade 4 and 5 of pathologic tumor response. Decrease of the oxygenation level was revealed in one patient with the 4th degree of tumor response. Variable changes of the oxygenation level were mentioned in the patients with moderate (the 3d degree) tumor response. Tumor oxygenation decreased or was unchanged in case of 1 or 2 degree of tumor response in five of six cases. The study of the tumor blood vessels didn't reveal any correlation between vasculature changes and tumor response under the performed treatment. The trend of tumor oxygenation in early time after treatment beginning might be a predictive criterion of tumor sensitivity to chemotherapy.
机译：有效的乳腺癌治疗需要评估在化学和热疗法期间肿瘤组织的代谢变化进行预测肿瘤反应。在治疗开始和接受术前化疗的16名患者之前进行治疗前进行肿瘤氧状态（通过电力多普勒模式中的超声检查）和肿瘤脉管系统（通过电力多普勒模式的超声检查）的评价。将这些指标的变化与肿瘤病理反应进行比较。根据肿瘤组织的变化，乳腺肿瘤证明了肿瘤氧的不同动态。在病理肿瘤反应4级和5级患者中的五个患者中观察到第一次化疗后肿瘤氧合的增加。在一个患者中揭示了氧合水平的降低，其中患有第4次肿瘤反应。中度（3D度）肿瘤反应的患者提到了氧合水平的可变变化。在六种情况下，肿瘤氧合减少或在1或2度肿瘤反应的情况下保持不变。肿瘤血管的研究没有揭示脉管系统变化与肿瘤反应在进行的治疗下的任何相关性。治疗开始后的早期肿瘤氧合的趋势可能是肿瘤对化疗的预测标准。

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