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首页> 外文会议>Optical tomography and spectroscopy of tissue XII >The complex evaluation of tumor oxygen state and vasculature during preoperative chemotherapy in patients with breast cancer
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The complex evaluation of tumor oxygen state and vasculature during preoperative chemotherapy in patients with breast cancer

机译：乳腺癌患者术前化疗期间肿瘤氧状态和脉管系统的综合评估

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Effective breast cancer treatment requires the assessment of metabolic changes of tumor tissue during chemo- and hormonotherapy for prediction tumor response. Evaluation of the dynamics of tumor oxygen state (by diffuse optical spectroscopy imaging) and tumor vasculature (by ultrasound investigation in power Doppler mode) was performed before treatment beginning and before the second cycle of chemotherapy in 16 patients who received preoperative chemotherapy. Changes of these indicators were compared then with tumor pathologic response. Breast tumors demonstrated different dynamics of tumor oxygenation depending on the changes of tumor tissue. The increase of the tumor oxygenation after the first cycle of chemotherapy was observed in five of six patients with grade 4 and 5 of pathologic tumor response. Decrease of the oxygenation level was revealed in one patient with the 4th degree of tumor response. Variable changes of the oxygenation level were mentioned in the patients with moderate (the 3d degree) tumor response. Tumor oxygenation decreased or was unchanged in case of 1 or 2 degree of tumor response in five of six cases. The study of the tumor blood vessels didn't reveal any correlation between vasculature changes and tumor response under the performed treatment. The trend of tumor oxygenation in early time after treatment beginning might be a predictive criterion of tumor sensitivity to chemotherapy.
机译：有效的乳腺癌治疗需要评估化学疗法和激素疗法期间肿瘤组织的代谢变化，以预测肿瘤反应。在治疗开始之前和化疗的第二个周期的化疗之前，对16例接受术前化疗的患者进行了肿瘤氧状态（通过扩散光谱成像）和肿瘤脉管系统（通过超声多普勒超声检查）的动力学评估。然后将这些指标的变化与肿瘤病理反应进行比较。乳腺肿瘤根据肿瘤组织的变化表现出不同的肿瘤氧合动力学。在第一个化学疗法的第一个周期后，在有4级和5级病理性肿瘤反应的6名患者中，有5名观察到了肿瘤氧合的增加。一名患有4级肿瘤反应的患者发现氧合水平降低。在中度（3d程度）肿瘤反应患者中提到了氧合水平的变化。在六分之五的病例中，如果肿瘤反应程度为1或2，则肿瘤氧合降低或保持不变。对肿瘤血管的研究没有显示在进行的治疗下脉管系统变化与肿瘤反应之间的任何相关性。在治疗开始后的早期，肿瘤氧合作用的趋势可能是肿瘤对化疗敏感性的预测标准。

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