Feline injection site sarcoma is a highly invasive cancer with a low metastatic rate. Definitive treatment focuses on local tumor control achieved by aggressive surgical resection +/- adjuvant radiotherapy. Adjuvant radiotherapy is used in an attemptto sterilize microscopic cancer cells that are not removed surgically.The likelihood of a surgical cure (i.e. removal of all cancer cells) depends on the size of the tumor, as this relates to extent of microscopic disease, and its location. When used with a definitive-intent, radiotherapy can be delivered pre- or postoperatively. Pre-operative radiation allows for a smaller radiation treatment field and, in many cases, more effective radiation delivery with less morbidity. Some worry about increased healing complications when aggressive surgery follows radiotherapy. This has not been the author's experience in cats with FISS.Multi-disciplinary communication and collaboration, especially between the surgical and radiation oncology teams, is key to optimal patient management.
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