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Cell Cycle as a Fault Tolerant Control System

机译:细胞周期作为容错控制系统

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We present models focused on the control mechanisms in cell cycle, allowing to predict the propagation of faults and its consequences for the cell fate. Development of such models is a two-stage process. First a graph representing molecules and interaction among them is built, through an extensive search of bioinformatic databases and publications. Such graph can be subsequently used to find cutting nodes, representing proteins or complexes or cutting edges, representing biochemical processes that are needed by control mechanisms. The second step is modeling and development of a dynamical model, e.g. in the form of ordinary differential equations that describe changes in concentration of the molecules involved in control mechanisms.
机译:我们提出了专注于细胞周期控制机制的模型,允许预测故障的传播及其对细胞命运的后果。 这些模型的发展是一个两阶段的过程。 首先,通过广泛地搜索生物信息管理数据库和出版物,构建代表分子和它们之间的互动的图。 随后可以用于找到切割节点,代表蛋白质或复合物或切削刃,代表控制机构所需的生物化学过程。 第二步是动态模型的建模和开发,例如, 以常微分方程的形式描述控制机制涉及的分子浓度的变化。

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