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首页> 外文会议>International Conference in One Health >Potency Combination of Curcumin (Curcuma longa Linn.) and Vitamin E toward Estrogen and Progesterone Profile on Rat (Ratttus norvegicus) Mammary Cancer Model
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Potency Combination of Curcumin (Curcuma longa Linn.) and Vitamin E toward Estrogen and Progesterone Profile on Rat (Ratttus norvegicus) Mammary Cancer Model

机译：姜黄素（Curcuma Longa Linn.）和维生素E对大鼠雌激素和孕酮谱的效力组合，ratttus norvegicus）乳腺癌模型

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This study aimed to determine the potency of combination of medicinal plants, which is curcumin and vitamin E as an alternative herbal for breast cancer treatment using DMBA ((7,12-Dimethylbenz(a)anthracene) induced rats (Rattus norvegicus) as animal model. The treatments were normal rats as negative control group (NCG), DMBA induced rats as breast cancer suffering rats or positive control group (PCG), and DMBA induced rats treated with combination of curcumin 72 mg per kg body weight per day and vitamin E 200 IU per head per day for 14 days as treated positive control group 1 (TPCG 1) and DMBA induced rats as breast cancer suffering rats or positive control group (PCG), and DMBA induced rats treated with combination of curcumin 48 mg per kg body weight per day and vitamin E 300 IU per head per day for 14 days as treated positive control group 2 (TPCG 2). Therapy of the DMBA induced rats was done per orally using combination of curcumin 72 mg per kg body weight per day and vitamin E 200 IU per head per day for 14 days. After the 14 days, euthanasia was done on the rats and blood samples were collected from each rat for laboratory analysis of estrogen and progesterone concentration using Enzyme Linked Immunosorbent Assay (ELISA) procedure. It was clearly shown that combination of curcumin 72 mg per kg body weight per day and vitamin E 200 IU per head per day has potential as an anti cancer therapy, as characterized by the decrease of blood estrogen concentration, the increase of blood progesterone concentration, and the disappearance of nodules in the breast tissues of cancer suffering animals.
机译：本研究旨在确定药用植物组合的效力，它是使用DMBA治疗乳腺癌治疗的替代草药（（7,12-二甲基（A）蒽）诱导的大鼠（Rattus Norvegicus）作为动物模型。治疗是正常的大鼠，作为阴性对照组（NCG），DMBA诱导大鼠作为患乳腺癌或阳性对照组（PCG），和DMBA诱导的大鼠用每只KG体重的姜黄素72mg的组合和维生素E.每天每天每天每天200 IU，治疗阳性对照组1（TPCG 1）和DMBA诱导的大鼠作为乳腺癌患者患有大鼠或阳性对照组（PCG），DMBA诱导的大鼠用姜黄素48mg的组合处理每公斤体每天每天重量和维生素E 300 IU每天14天，如治疗的阳性对照组2（TPCG 2）。使用每kg体重每天每天的姜黄素72mg的组合进行DMBA诱导的大鼠的治疗E 20.每天每天0 iu为14天。在14天后，在大鼠中完成了Euthanasia，使用酶联免疫吸附测定（ELISA）程序从每只大鼠中收集大鼠的实验室分析。清楚地表明，每天每千克体重的姜黄素72mg的组合每天维生素E 200 IU每天具有抗癌治疗，其特征在于血液雌激素浓度的降低，血液孕酮浓度的增加，癌症患有动物的乳腺组织中结节的消失。

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