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首页> 外文会议>International Conference on "Times of Polymers and Composites" >Preparation of sol-gel organic-inorganic hybrid coatings for controlled drug release
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Preparation of sol-gel organic-inorganic hybrid coatings for controlled drug release

机译：控制药物释放溶胶 - 凝胶有机 - 无机杂交涂层的制备

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The need to improve the tolerability and life time of the metallic implants, lead our research group to develop implantable therapeutic systems able to release an anti-inflammatory agent in the implant site. Therefore, in the present work, a sol-gel dip coating route has been optimized to coat titanium implant with two organic-inorganic hybrid materials: the first consisted of a glass zirconia matrix in which indomethacin (IND) was embedded, the second of a zirconia glass, the polyester poly (ε-caprolactone) (PCL) and the IND. PCL was added into the materials to modulate the release kinetic of the IND. Moreover, coatings consisting of a different numbers of layers, were applied to a substrates to modulate the dosage of the released drug. The obtained coatings were characterized and the drug release was investigated as a function of the PCL content and of the layers' number.
机译：需要改善金属植入物的耐受性和终生时间，引导我们的研究组开发植入治疗系统，能够在植入部位释放抗炎剂。因此，在本作本作中，已经优化了溶胶 - 凝胶浸涂途径，用两个有机 - 无机杂交材料涂覆钛植入物：首先由玻璃氧化锆基质组成，其中嵌入吲哚美辛（Ind），第二个氧化锆玻璃，聚酯聚（ε-己内酯）（PCL）和IND。将PCL加入到材料中以调节IND的释放动力学。此外，由不同数量的层组成的涂层被施加到基材上以调节释放的药物的剂量。表征了所得涂层，并作为PCL含量和层数的函数研究药物释放。

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