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An Ultra-Fast and Large-Scale Fabrication Method for Paper-Based Microfluidic Chips

机译：一种超快速和大规模的纸张微流体芯片制造方法

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Portable electronic devices and wireless communication enable a broad range of applications including environmental surveillance, food safety monitoring and point-of-care testing. Particularly, by incorporating smartphone and micro-fluidic paper-based device, rapid analysis, mobile laboratories for chemical assay, remote sensing and data management become more available. In this work, we designed and fabricated a 12-unit paper chip for colorimetric detection of metals. 48 chips can be obtained on a single A4 size paper within 5 min. Additive manufacturing technology was employed to construct the experimental platform. A cellphone's camera was used to capture colorimetric images, and then the RGB values of the color images were converted to grayscale via a self-built App. The intensity reflecting metal concentrations were processed and analyzed by the same app and a remote server. To demonstrate the utility of this approach, Fe solutions were tested. The detection limit of this method is 0.2 μg. The presented device and data processing tools hold a potential to assist mobile sensing, pollution detection and healthcare in routine work.
机译：便携式电子设备和无线通信实现广泛的应用，包括环境监控，食品安全监控和护理点测试。特别是，通过纳入智能手机和微流体纸的装置，快速分析，移动实验室进行化学测定，遥感和数据管理变得更加可用。在这项工作中，我们设计并制造了一个12单元纸芯片，用于测色的金属检测。在5分钟内，可以在单个A4尺寸纸上获得48个芯片。采用添加剂制造技术来构建实验平台。手机的相机用于捕获比色图像，然后通过自画本应用将彩色图像的RGB值转换为灰度。通过相同的应用程序和远程服务器处理和分析反映金属浓度的强度。为了证明这种方法的效用，测试了Fe解决方案。该方法的检测限为0.2μg。所提出的设备和数据处理工具具有助致在常规工作中提供移动感应，污染检测和医疗保健的可能性。

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