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首页> 外文会议>International Conference on Applications of Optics and Photonics >Development of NiFe_2O_4/Au nanoparticles covered with lipid bilayers for applications in combined cancer therapy
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Development of NiFe_2O_4/Au nanoparticles covered with lipid bilayers for applications in combined cancer therapy

机译：NiFe_2O_4 / AU纳米粒子覆盖的NiFe_2O_4 / Au纳米颗粒用于组合癌症治疗中的应用

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The potential of nanosystems with combined magnetic and plasmonic properties for biomedical applications has been recognized. Magnetic nanoparticles can enable magnetic drug targeting and hyperthermia, while plasmonic gold nanoparticles ensure effective local heating (photothermia) using relatively low energies for gold excitation. Considering cancer therapy, the combination of magnetic and plasmonic capabilities in a single multifunctional nanosystem allows magnetic guidance and production of local heat, the latter promoting triggered drug release and synergistic cytotoxic effect in cancer cells (combined chemo/phototherapy). In this work, magnetic/plasmonic nanoparticles of nickel ferrite/gold were prepared, including core/shell nanoparticles (with a nickel ferrite magnetic core and a gold plasmonic shell) and nickel ferrite nanoparticles decorated with gold nanoparticles. In order to develop applications in combined cancer therapy, the prepared nanoparticles were covered with a lipid bilayer, these systems being able to transport drugs. The heating capabilities of the nanosystems were evaluated through the fluorescence quenching of the dye rhodamine B incorporated in the lipid bilayer upon excitation with a light source. The developed multifunctional nanosystems have shown promising results for application in combined cancer therapy (chemo/phototherapy).
机译：与生物医学应用合成磁场和电浆纳米系统性能的潜力已经得到了认可。磁性纳米颗粒可以使磁性药物靶向和热疗，而等离激元的金纳米颗粒确保有效的局部加热（photothermia）使用相对低的能量为金激励。考虑癌症治疗，在一个单一的多官能纳米系统磁性和电浆能力组合允许磁性引导和生产局部热的，后者促进触发药物释放和在癌细胞中的协同细胞毒性作用（组合化学/光疗）。在这项工作中，镍铁素体的磁性/等离子体纳米颗粒/金制备，包括装饰有金纳米颗粒的核/壳纳米颗粒（与镍铁氧体磁芯和金电浆壳）和镍铁素体纳米粒子。为了发展综合癌症治疗的应用，制备的纳米颗粒上覆盖脂质双层，这些系统能够运输毒品。所述纳米系统的加热能力是通过在脂质双层中时激发用光源并入染料若丹明B的荧光猝灭进行评价。所开发的多功能纳米系统已显示有希望用于在组合的癌症治疗（化学/光疗）应用程序的结果。

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