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Synthesis And Characterization of Two Types of Heterogeneous Rings Derived from Sulfamethoxazole and Evaluation Their Bacterial Activity

机译:巯基嘧唑两种异质环的合成与表征,并评价其细菌活性

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In this research include preparation three steps of the new derivatives of Sulfamethoxazole drug, the first step involved converting Sulfamethoxazole to Schiff s bases (1), by reaction Sulfamethoxazole with different specific aldehydes in ethanol, presence in glacial acetic acid. While the second step involved reaction Schiffs bases (1) with sodium azide in presence of Benzene (dry) to give new tetrazole derivatives (2). Finally, The third reaction requires synthesis of thiazolidine (3) by reaction of Schiffs bases (1) with 2-mercaptoacetic acid. The prepared compounds were characterized by physical properties, and somewhat of them by IR, 1H-NMR spectroscopy, and study biologic efficacy against two types of bacteria.
机译:在该研究中,包括制备磺胺甲恶唑的新衍生物的三个步骤,通过在乙醇中具有不同特异性醛的反应磺胺甲氧唑来转化磺胺甲恶唑至Schiff S碱(1)的第一步。虽然第二步涉及反应Schiffs碱(1)含氮化钠(干燥),得到新的四唑衍生物(2)。最后,第三反应需要通过Schiffs碱(1)与2-巯基乙酸的反应合成噻唑烷(3)。制备的化合物的特征在于物理性质,用IR,1H-NMR光谱学和稍微通过IR,1H-NMR光谱和研究两种细菌的​​生物学疗效。

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