• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>International Conference on Bioinformatics and Nanomedicine from Natural Resources for Biomedical Research >Efficacy and Side Effects Studies of Bryophyllumpinnatum leaves ethanol extract in pristane-induced SLE BALB/c mice model
【24h】

Efficacy and Side Effects Studies of Bryophyllumpinnatum leaves ethanol extract in pristane-induced SLE BALB/c mice model

机译：青霉属植物叶片含有丙烷诱导的SLAP / C小鼠模型中乙醇提取物的疗效和副作用研究

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of our study was to investigate the efficacy of Bryophyllum pinnatum leaves ethanol extract in pristane-induce systemic lupus erythematosus (SLE) BALB/c mice model. Forty female BALB/c mice, aged 6-8 weeks old received a single i.p. injection of 0.5 cc pristane for lupus induction. 16 weeks after injection, pristane-induced lupus mice were divided into four groups based on the doses of Bryophyllum pinnatum received intragastrically: 0, 10.5 mg/kg/, 21 mg/kg/, and 42 mg/kg/day for 12 weeks. At 38 weeks after injection, all mice were assessed for inflammation marker. Side effects study results suggest that there were no signs of side effects generally. No significant changes of blood pressure, liver and mice renal function were observed. The efficacy study showed that percentages of matured B cells, TNF-a, CRP, IL-17, and IL-12 decreased (p<0.05) and percentages of TGF-β and complement C3 and C4 increased (p>0.05) in Bryophyllum pinnatum treated mice. Bryophyllum pinnatum crude extract has the potential to be further developed as a new, safe, and effective agent of delivery to modulate immune cells against pristane-induced SLE BALB/c mice.
机译：我们的研究目的是探讨白痴植物叶子乙醇提取物在常见的全身性红斑狼疮（SLE）BALB / C小鼠模型中的乙醇提取物的疗效。四十雌性Balb / c小鼠，年龄6-8周龄，接受了一个I.P.针对狼疮诱导注射0.5 CC丙酮。注射后16周，基于胃内接受的血细胞碱的剂量分为四组血管血管小鼠：0,1.5mg / kg /,21mg / kg /,22mg / kg /天12周。注射后38周，评估所有小鼠的炎症标志物。副作用研究结果表明，通常没有副作用的迹象。没有观察到血压，肝脏和小鼠肾功能的显着变化。疗效研究表明，经成熟的B细胞，TNF-A，CRP，IL-17和IL-12的百分比降低（P <0.05）和TGF-β和补体C3和C4的百分比（P> 0.05）在细胞中增加（p> 0.05）食指治疗小鼠。细冻植物粗提取物具有进一步发展的潜力作为一种新的，安全和有效的递送剂，以调节免疫细胞对常规诱导的SLE BALB / C小鼠。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号