The Study of the Transgeneration Genotoxic Effect of Drugs Based on the Analysis of Synaptonemal Complexes in Mouse Spermatocytes

机译：基于药物分析在小鼠精子囊细胞中的突触骨膜复合物分析的转基因毒毒性效应研究

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The research employs immmunocytochemical methods to study the synaptonemal complexes (SC), and it targets the primary spermatocytes of mice from the offspring of males who received antimicrobials The males in the offspring of fathers received bacteriophage, nitrofural and cifran. When comparing the total number of damaged cells, they did not show a significant difference with the control animals. However, when comparing the spectrum of affects, they presented a significantly increased number of cells having ring SC-bivalents in the offspring of males treated with cifran. This may indicate an increase in chromosome fragility, leading to the deletion of telomere regions of chromosomes, which in turn causes the formation of ring bivalents.

机译：该研究采用免疫细胞化学方法来研究Synaponemal复合物（SC），它靶向小鼠的原发性精子，从父亲接受父亲的后代接受抗菌药物，占菌体，氮杂物和西联人的雄性的后代。当比较受损细胞总数时，它们没有与对照动物显着差异。然而，当比较影响的频谱时，它们呈现出在用CiFran处理的雄性的后代具有环Sc-Bivivalents的显着增加的细胞数。这可能表明染色体脆性的增加，导致染色体的端粒区域缺失，这反过来导致环比的形成。

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《International Conference on Engineering and Earth Sciences》|2019年|577p|共5页
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Maret M. Atsayeva; Zura I. Bisultanova; Petimat M. Dzhambetova; Nadezhda Yu. Oyun; Oksana L. Kolomiets;
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中图分类 TB-53;
关键词
Synaptonemal complex; Meiosis; Transgeneration effect; Drugs; Genotoxicity;

机译：Synaponemal Complex;减数分裂;转子效应;毒品;基因毒性;

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专利

1. Synaptonemal complexes are integral components of the isolated mouse spermatocyte nuclear matrix. [J] . L A Ierardi, S B Moss, A R Bellvé Journal of cell biology . 1983,第6期

机译：突触复合物是分离的小鼠精细胞核基质的组成部分。
2. Damage to synaptonemal complex structure and peculiarities of selection of mouse spermatocytes I at response to drug administration [J] . Kolomiets O.L., Atsaeva M.M., Dadashev S.Y., Russian journal of genetics . 2013,第11期

机译：给药后对小鼠突触复合体结构的损害和小鼠精子I的选择特性
3. Meiotic cohesin subunits RAD21L and REC8 are positioned at distinct regions between lateral elements and transverse filaments in the synaptonemal complex of mouse spermatocytes [J] . Rong Mei, Matsuda Atsushi, Hiraoka Yasushi, The Journal of Reproduction and Development . 2016,第6期

机译：减数分裂粘附素亚基RAD21L和REC8位于小鼠精母细胞突触复合物中侧向元素和横向细丝之间的不同区域
4. The Study of the Transgeneration Genotoxic Effect of Drugs Based on the Analysis of Synaptonemal Complexes in Mouse Spermatocytes [C] . Maret M. Atsayeva, Zura I. Bisultanova, Petimat M. Dzhambetova, International Conference on Engineering and Earth Sciences . 2019

机译：基于药物分析在小鼠精子囊细胞中的突触骨膜复合物分析的转基因毒毒性效应研究
5. Investigations of the biodistribution and phototherapeutic utility of two palladium(II)-containing macrocyclic drugs in a tumour-bearing mouse model: A study of the pharmacokinetics and tissue distribution of the potential photodynamic drug palladium-bacteriopheophorbide as well as the in vivo treatment efficacy and tissue distribution of the potential photothermal drug palladium(II) octabutoxynaphthalocyanine. [D] . DeGroot, Jennifer Leanne. 2002

机译：两种含钯（II）的大环药物在荷瘤小鼠模型中的生物分布和光疗实用性的研究：潜在的光动力药物钯-细菌脱镁叶绿酸的药代动力学和组织分布以及体内治疗效果和研究光热药物钯（II）八丁氧基萘酞菁的组织分布。
6. Synaptonemal complexes are integral components of the isolated mouse spermatocyte nuclear matrix [O] . 1983

机译：突触复合物是分离的小鼠精细胞核基质的组成部分
7. The Study of the Transgeneration Genotoxic Effect of Drugs Based on the Analysis of Synaptonemal Complexes in Mouse Spermatocytes [O] . Maret M. Atsayeva, Zura I. Bisultanova, Petimat M. Dzhambetova, 2018

机译：基于药物分析在小鼠精子囊细胞中的突触骨膜复合物分析的转基因毒毒性效应研究
8. Stage-Specific Damage to Synaptonemal Complexes and Metaphase Chromosomes Inducedby X Rays in Male Mouse Germ Cells [R] . Backer, L. C., Sontag, M. R., Allen, J. W. 1991

机译：对雄性小鼠生殖细胞中X射线诱导的联会复合体和中期染色体的阶段特异性损伤

The Study of the Transgeneration Genotoxic Effect of Drugs Based on the Analysis of Synaptonemal Complexes in Mouse Spermatocytes

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