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Preparation and Characterisation of Gellan Gum Hydrogel containing Curcumin and Limonene

机译:含姜黄素和柠檬烯的Gellan Gum水凝胶的制备与表征

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Success in wound treatment requires careful assessment on the wound and suitable wound dressing. In this project a novel incorporation of both curcumin and limonene into gellan gum hydrogel have been done. This system is believed to have a better permeation of curcumin to the target area. The samples prepared are denoted as GGTF for gellan gum thin film, Cur-GGTF for curcumin gellan gum thin film. Samples of Cur-GGTF incorporated with limonene with three different concentrations of 0.0005 M, 0.0006 M and 0.0007 M are known as CurLim-GGTF05, CurLim-GGTF06 and CurLim-GGTF07, respectively. The hydrogels were crosslinked by calcium ion. From the FTIR analysis, all of the expected functional groups from the gellan gum, curcumin and limonene were found present in the hydrogel samples. The TGA-DTG analysis has proven that the incorporation of limonene into hydrogels has decreased the thermal stability of the hydrogels. The addition of limonene has caused a hike in the gel fractions of the hydrogels. The water vapour transmission rate (WVTR) and swelling test showed that the introductions of high concentrations of limonene into the hydrogels have hampered the absorption of water molecules thus causing the swelling degree to decrease.
机译:伤口治疗的成功需要对伤口和合适的伤口敷料进行仔细评估。在该项目中,已经完成了一种新的姜黄素和柠檬烯掺入Gellan Gum Hydrogel。该系统被认为具有更好的姜黄素渗透到目标区域。制备的样品表示为Gellan Gum薄膜的GGTF,Cur-GGTF用于姜黄素Gellan Gum薄膜。与具有三种不同浓度为0.0005μm,0.0006μm和0.0007μm的柠檬烯的Cur-GGTF样品分别称为Curlim-GGTF05,Curlim-GGTF06和Curlim-GGTF07。水凝胶通过钙离子交联。从FTIR分析中,发现来自Gellan Gum,姜黄素和柠檬烯的所有预期官能团存在于水凝胶样品中。 TGA-DTG分析证明,将柠檬烯掺入水凝胶的掺入水凝胶的热稳定性降低。加入柠檬烯在水凝胶的凝胶级分中引起了远足。水蒸气透射率(WVTR)和溶胀试验表明,将高浓度的柠檬烯的介绍妨碍了水分子的吸收,从而导致溶胀程度降低。

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