Review on the Changes of Cytokines after Traumatic Brain Injury

机译：创伤性脑损伤后细胞因子的变化回顾

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Inflammatory response after traumatic brain injury plays an essential role in secondary brain injury. Cytokines, as critical inflammatory mediators in vivo, are involved in a variety of pathophysiological processes and play a significant role in the inflammatory cascade after brain injury. There are two kinds of cytokines involved in secondary brain injury and repair after brain trauma: pro-inflammatory cytokines and anti-inflammatory cytokines. Among them, nuclear factor kB(NF-kB), tumor necrosis factor a(TNF-a), soluble intercellular adhesion molecule l(sICAM-l), vascular endothelial adhesion molecule 1(VCAM-1 ), and interleukin 1β(IL-1β), IL-6, IL-8, IL-16 are the major pro-inflammatory cytokines; IL-2, IL-4, IL-10 and IL-13are anti-inflammatory cytokines. This paper mainly summarizes the current research status of inflammatory cytokines, reaction mechanism and its relationship with TBI secondary brain injury.

机译：创伤性脑损伤后的炎症反应在次生脑损伤中起重要作用。作为体内临性炎症介质的细胞因子涉及各种病理生理过程，并在脑损伤后炎症级联发挥重要作用。脑创伤后有两种细胞因子参与继发性脑损伤和修复：促炎细胞因子和抗炎细胞因子。其中，核因子KB（NF-KB），肿瘤坏死因子A（TNF-A），可溶性细胞间粘附分子L（SICAM-L），血管内皮粘附分子1（VCAM-1）和白细胞介素1β（IL- 1β），IL-6，IL-8，IL-16是主要的促炎细胞因子; IL-2，IL-4，IL-10和IL-13ARE抗炎细胞因子。本文主要总结了炎性细胞因子，反应机制及其与TBI继发性脑损伤关系的目前研究状态。

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《International Conference on Frontiers of Biological Sciences and Engineering》|2020年|1 volume (various pagings) :|共6页
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Yayue Zhou;
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中图分类 Q81-532;
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Inflammatory response; TBI; cytokines;

机译：炎症反应;TBI;细胞因子;

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2. Cerebrospinal Fluid and Microdialysis Cytokines in Severe Traumatic Brain Injury: A Scoping Systematic Review [J] . Frederick A. Zeiler, Eric Peter Thelin, Marek Czosnyka, Frontiers in Neurology . 2017,第2016期

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4. Review on the Changes of Cytokines after Traumatic Brain Injury [C] . Yayue Zhou International Conference on Frontiers of Biological Sciences and Engineering . 2020

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7. Traumatic Brain Injury and Delayed Sequelae: A Review - Traumatic Brain Injury and Mild Traumatic Brain Injury (Concussion) are Precursors to Later-Onset Brain Disorders, Including Early-Onset Dementia [O] . Michael A. Kiraly, Stephen J. Kiraly 2007

机译：颅脑外伤和后遗症延迟：综述-颅脑外伤和轻度颅脑外伤（脑震荡）是包括早发性痴呆在内的后发性脑疾病的先兆

Review on the Changes of Cytokines after Traumatic Brain Injury

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